期刊
CARBOHYDRATE POLYMERS
卷 291, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119628
关键词
CH -? interaction; Hydrogen bonding; Starch-based prodrugs; Porous materials; In-vivo fate
资金
- National Natural Science Foundation of China [31571794]
- Guangxi Natural Science Foundation [2019GXNSFBA245029]
- National First-class Discipline Program of Food Science and Technology [JUFSTR20180204]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX21_2046]
This review discusses the research progress of starch and its derivatives as carriers for enhancing and reducing toxicity of paclitaxel, as well as their complex properties and role as permeability enhancers.
Paclitaxel, a clinical chemotherapy drug commonly used in the past few years, is greatly limited by its low therapeutic index. Starch and its derivatives have gained wide interest from researchers owing to their unique hydrophilic and hydrophobic properties resulting from their various modifications, which exert the effectenhancing and toxicity-reducing activity to paclitaxel in vivo and in vitro. This review summarizes the research progress toward different kinds of starch-based carriers, whether oral or injectable. In addition, we discuss the complex properties of starch derivatives toward physically complexed or chemically conjugated paclitaxel. The corresponding complex configurations are suggested. Starch-based carriers can act as permeability enhancers because they may interact with the unstirred water layer that separates hydrophobic drugs from biological membranes, even altering the barrier properties of the membrane. The information presented in this review may be used as a reference for future hydrophobic drug carrier studies.
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