4.7 Review

Regulation of biomineralization by proteoglycans: From mechanisms to application

期刊

CARBOHYDRATE POLYMERS
卷 294, 期 -, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119773

关键词

Proteoglycans; Biomineralization; Glycosaminoglycans; Bone tissue engineering; Pathological mineralization

资金

  1. National Natural Science Foundation of China [81870805, 82100971]
  2. Shaanxi Key Scientific and Technological Innovation Team [2020TD-033]
  3. Youth Innovation Team of Shaanxi Universities
  4. innovative research team of high-level local universities in shanghai

向作者/读者索取更多资源

This review focuses on the potential mechanisms of proteoglycans-mediated biomineralization, including their roles in regulating cell proliferation and differentiation, collagen fibril aggregation, and mineral deposition. Proteoglycans play important roles in bone tissue engineering and as therapeutic targets for ectopic mineralization.
Proteoglycans consist of core proteins and one or more covalently-linked glycosaminoglycan chains. They are structurally complex and heterogeneous. Proteoglycans bind to cell surface receptors, cytokines, growth factors and have strong affinity for collagen fibrils. Together with their complex spatial structures and different charge densities, proteoglycans are directly or indirectly involved in biomineralization. The present review focused on the potential mechanisms of proteoglycans-mediated biomineralization. Topics covered include the ability of proteoglycans to influence the proliferation and differentiation of odontoblasts and osteoblasts through complex signaling pathways, as well as regulate the aggregation of collagen fibrils and mineral deposition. The functions of proteoglycans in mineralization regulation and biomimetic properties render them important components in bone tissue engineering. Hence, the integrated impact of proteoglycans on bone formation was also succinctly deliberated. The potential of proteoglycans to function therapeutic targets for relieving the symptoms of ectopic mineralization and mineralization defects was also comprehensively addressed.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据