期刊
CANCER LETTERS
卷 546, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2022.215840
关键词
Adoptive cell therapy; Personalized immunotherapy; Public neoantigen; Solid tumors; TCR
类别
资金
- National Natural Science Foundation of China [82072926, 81930080, 81872146]
- Natural Science Foundation of Jiangsu Province [BK20191114]
- Nanjing Medical Science and Technique Development Foundation [QRX17038]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX20-1484]
TCR-T cell therapy targeting neoantigens shows promise for solid tumor immunotherapy. Despite the increasing efficiency and productivity in manufacturing TCR-T cells, clinical-scale production still faces significant challenges. This review summarizes the latest progress in neoantigen-targeted TCR-T cell therapy and discusses the technical difficulties in personalized preparation and the challenges in clinical applications.
T cell receptor-engineered T (TCR-T) cells targeting neoantigens present potential immunotherapy for solid tumors. With the continuous optimization of the entire production procedures, the manufacturing process of TCR-T cells is becoming more efficient and productive. However, clinical-scale manufacturing of TCR-T cells still encounters tremendous challenges. Here, we summarize the latest progress of neoantigen-targeted TCR-T cell therapy and focus on the technical difficulties in preparing personalized neoantigen-targeted TCR-T cells and the challenges in clinical applications. Possible approaches for improving TCR-T cell therapy are discussed as well in this review.
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