期刊
CANCER LETTERS
卷 546, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2022.215860
关键词
Therapy resistance; Metastasis; Immune escape; CAFs activation; CAFs-targeted therapies
类别
资金
- National Natural Science Foundation of China [81872477]
- Natural Science Foundation of Zhejiang province
In this review, the impact of cancer-associated fibroblasts (CAFs) on esophageal squamous cell carcinoma (ESCC) is highlighted, including the induction of chemoresistance, radioresistance, migration, invasion, and immune escape. The origin of CAFs and the influence of ESCC cells on CAF activation are also discussed. Furthermore, the clinical prospects and future trends of CAFs-targeted therapies in ESCC are emphasized. A better understanding of the molecular biology of CAFs may contribute to the development of novel anti-ESCC strategies.
Esophageal squamous cell carcinoma (ESCC) is one of the most common human malignancies worldwide and is associated with high morbidity and mortality. More than 70% of ESCC patients are diagnosed at the intermediate or advanced stage. Concurrent chemoradiotherapy is the standard treatment regimen for patients with advanced ESCC. However, ESCC patients show a poor 5-year survival rate of around 20%. Cancer-associated fibroblasts (CAFs) are a major component of the tumor microenvironment and control tumor initiation and progression. CAFs create a pro-survival and immunosuppressive microenvironment by crosstalk with cancer cells. Moreover, CAFs lead the collective invasion of cancer cells of the epithelial phenotype by remodeling the extracellular matrix. In this review, we highlight the impact of CAFs on ESCC, including induction of chemo-and radio -resistance, migration, invasion, and immune escape. The origin of CAFs and the influence of ESCC cells on CAF activation are also described. Furthermore, we highlight the clinical prospects and future trends of CAFs-targeted therapies in ESCC. A better understanding of the molecular biology of CAFs may contribute to the development of novel anti-ESCC strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据