期刊
CANCER LETTERS
卷 546, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2022.215854
关键词
Head and neck cancer; Ferroptosis; Treatment; Iron; Lipid peroxidation
类别
资金
- National Research Foundation of Korea (NRF)
- Ministry of Science and ICT (MSIT) , The Government of Korea [2019R1A2C2002259]
Most head and neck cancers originate from mucosal epithelial cells. The loss of epithelial traits by the epithelial-mesenchymal transition may render cells vulnerable to ferroptosis, a novel non-apoptotic regulated cell death, by the iron-dependent accumulation of excessive lipid peroxidation. This article discusses the potential effect of ferroptosis induction as a novel treatment for resilient head and neck cancers.
Most head and neck cancers (HNCs) originate from mucosal epithelial cells and show epithelial traits. It often changes to a mesenchymal or poorly differentiated state as cancer progresses, leading to invasion, metastasis, and resistance to treatment. The loss of epithelial traits by the epithelial-mesenchymal transition may render resilient cancers vulnerable to a novel non-apoptotic regulated cell death ferroptosis by the iron-dependent accumulation of excessive lipid peroxidation. By regulating mitochondrial or iron metabolism, intracellular ferrous iron and lipid peroxidation accumulation can be boosted, making resistant cancer cells more susceptible to ferroptosis. This article discusses the potential effect of ferroptosis induction as a novel treatment for resilient HNCs.
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