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PI3K Inhibition for Squamous Cell Head and Neck Carcinoma

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CANCER JOURNAL
卷 28, 期 5, 页码 369-376

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LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PPO.0000000000000618

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Head and neck squamous cell carcinoma; PI3K inhibitors; targeted therapy

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The PI3K pathway is abnormally activated in head and neck squamous cell carcinomas, making it a valuable target for targeted therapy. Multiple PI3K inhibitors have been studied but have shown unfavorable risk-benefit ratios in unselected patient populations. Buparlisib, a potent pan-class I PI3K inhibitor, has shown promising efficacy when combined with paclitaxel for advanced head and neck squamous cell carcinoma. Results of the phase III BURAN trial are pending.
The phosphoinositide 3-kinase (PI3K) pathway is aberrantly activated in most head and neck squamous cell carcinomas, making it a prized target for targeted therapy development. Multiple PI3K inhibitors have been studied in early phase trials, with unfavorable risk-benefit ratios in molecularly unselected patient populations. Buparlisib, a potent pan-class I PI3K inhibitor, shows promising efficacy in combination with paclitaxel for advanced head and neck squamous cell carcinoma. Results of the phase III BURAN trial are awaited.

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