期刊
CANCER INVESTIGATION
卷 40, 期 10, 页码 852-867出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07357907.2022.2134415
关键词
Nevus; early melanoma; diagnosis; marker; immunohistochemistry
类别
This review analyzes the effectiveness of 20 molecules as immunohistochemical markers in distinguishing dysplastic and/or Spitz nevi from early melanomas. The results show significant differences in the presence and/or levels of six potential markers in early melanomas compared to dysplastic nevi, and seven potential markers in early melanomas compared to Spitz nevi. The most promising results were obtained for 5-hydroxymethylcytosine, cyclooxygenase-2, and PReferentially expressed Antigen in MElanoma.
Although most melanocytic skin lesions are correctly diagnosed, numerous studies have shown interobserver disagreement. This review analyzes 20 molecules as immunohistochemical markers for distinguishing dysplastic and/or Spitz nevi from early melanomas (in situ, Clark level I or II and/or Breslow thickness at most 1 mm). The detected presence and/or level of tested molecules was significantly different in early melanomas than in dysplastic and Spitz nevi for six and seven potential markers, respectively. The most promising results were obtained for 5-hydroxymethylcytosine, cyclooxygenase-2 and PReferentially expressed Antigen in MElanoma whose levels were different in dysplastic and Spitz nevi compared to early melanomas.
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