Unpacking circulating tumor DNA lends insight into prostate cancer biology and the clonal dynamics of metastasis

Prostate cancer (PCa) frequently metastasizes to bone, and analyses of DNA from bone biopsies are excep-tionally challenging. A recent report in Nature demonstrates that whole-genome sequencing (WGS) of circu-lating tumor DNA (ctDNA) from patients with metastatic PCa can inform on the subclonal composition of met-astatic disease and infer patterns of gene expression.

Automated summary

A recent report in Nature demonstrates that whole-genome sequencing of circulating tumor DNA from patients with metastatic PCa can inform on the subclonal composition of metastatic disease and infer patterns of gene expression.