4.4 Article

Multimarker Responses of Zebrafish to the Effect of Ibuprofen and Gemfibrozil in Environmentally Relevant Concentrations

期刊

出版社

SPRINGER
DOI: 10.1007/s00128-022-03607-2

关键词

Danio rerio; gemfibrozil; ibuprofen; oxidative stress; endocrine disruption; protein carbonyls

资金

  1. Ministry of Education and Science of Ukraine [MV-2]
  2. National Research Foundation of Ukraine [2020.02/0270]
  3. Alexander von Humboldt Foundation
  4. DAAD

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Pharmaceutical pollution of water bodies, including ibuprofen and gemfibrozil, has significant effects on the health and antioxidant defense system of zebrafish.
Pharmaceutical pollution of water bodies is among the top-notch environmental health risks all over the world. The aim of the present study was to investigate the effects of two common pharmaceuticals namely ibuprofen and gemfibrozil on zebrafish at environmentally relevant concentrations. In zebrafish liver, gemfibrozil caused a decrease in glutathione and glutathione transferase and an increase in catalase but had no effect on lipid peroxidation and protein carbonylation. Ibuprofen altered the antioxidant defense system, promoted protein carbonylation in zebrafish liver, and increased vitellogenin-like protein in the blood. Ibuprofen and particularly gemfibrozil induced lysosomes biogenesis. Lactate dehydrogenase in the blood was also found to be higher in the studied groups. Studied pharmaceuticals did not affect complex II of the electron respiratory chain. Ibuprofen affects zebrafish health status more profoundly than gemfibrozil. Our results showed that pharmaceuticals even in low, environmentally realistic concentrations, induced profound changes in the stress-responsive systems of zebrafish.

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