期刊
BRITISH JOURNAL OF SPORTS MEDICINE
卷 56, 期 20, 页码 1157-1170出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/bjsports-2021-105132
关键词
-
资金
- European Union [634935, 633784]
- PERSPECTIVE I&I project by the Government of Canada through Genome Canada
- Canadian Institutes of Health Research
- Ministere de l'Economie et de l'Innovation du Quebec through Genome Quebec
- Quebec Breast Cancer Foundation
- National Cancer Institute Intramural Research Program, National Institutes of Health
- NIH [U19 CA148065, CA58860, CA92044]
- Cancer Research UK Grant [C1287/A16563, C490/A10124, C490/A16561]
- PERSPECTIVE project - Government of Canada through Genome Canada
- Canadian Institutes of Health Research [GPH-129344]
- Ministere de l'Economie, Science et Innovation du Quebec through Genome Quebec
- European Community [223175 (HEALTH-F2-2009-223175)]
- Cancer Research UK [C1287/A10118, C1287/A10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565, C1275/A11699, C1275/C22524, C1275/A19187, C1275/A15956]
- National Institutes of Health [CA128978]
- Post-Cancer GWAS initiative [1U19 CA148537, 1U19 CA148065, 1U19 CA148112]
- Department of Defence [W81XWH-10-1-0341]
- Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer
- Komen Foundation for the Cure
- Breast Cancer Research Foundation
- Ovarian Cancer Research Fund
- Wellcome Trust [v203477/Z/16/Z]
- National Cancer Institute (USA) [UM1 CA164920]
- National Health and Medical Research Council of Australia
- New South Wales Cancer Council
- Victorian Health Promotion Foundation (Australia)
- Victorian Breast Cancer Research Consortium
- Dutch Cancer Society [NKI 2007-3839, 2009 4363, RUL 1997-1505, DDHK 2004-3124, DDHK 2009-4318]
- The Cancer Institute NSW
- National Breast Cancer Foundation
- intramural research program of the National Institutes of Health
- National Cancer Institute [UM1 CA164920, Z01-CP010119, P50 CA058223, U54 CA156733, U01 CA179715]
- National Institute of Environmental Health Sciences [Z01-ES049030]
- ELANFond of the University Hospital of Erlangen
- Cancer Research UK
- Breast Cancer Now
- NHS
- National Health and Medical Research Council, Australia
- Cancer Council Western Australia
- Breast Cancer Research Foundation (BCRF)
- Accion Estrategica de Salud del Instituto de Salud Carlos III [FIS PI12/02125]
- FEDER [PI17/00918]
- Accion Estrategica de Salud del Instituto de Salud Carlos III FIS Intrasalud [PI13/01136]
- Programa Grupos Emergentes, Cancer Genetics Unit, Instituto de Investigacion Biomedica Galicia Sur. Xerencia de Xestion Integrada de Vigo-SERGAS, Instituto de Salud Carlos III, Spain
- Conselleria de Industria Programa Sectorial de Investigacion Aplicada, PEME I + D e I + D Suma del Plan Gallego de Investigacion, Desarrollo e Innovacion Tecnologica de la Conselleria de Industria de la Xunta de Galicia, Spain [10CSA012E]
- Fomento de la Investigacion Clinica Independiente, Ministerio de Sanidad, Servicios Sociales e Igualdad, Spain [EC11-192]
- FEDERInnterconecta. Ministerio de Economia y Competitividad, Xunta de Galicia, Spain
- Dietmar-Hopp Foundation
- Helmholtz Society
- German Cancer Research Center (DKFZ)
- Canadian Cancer Society [313404]
- University of Crete
- Fondation de France
- Institut National du Cancer (INCa)
- Ligue Nationale contre le Cancer
- Agence Nationale de Securite Sanitaire, de l'Alimentation, de l'Environnement et du Travail (ANSES)
- Agence Nationale de la Recherche (ANR)
- Chief Physician Johan Boserup and Lise Boserup Fund
- Danish Medical Research Council
- Herlev and Gentofte Hospital
- The American Cancer Society
- National Cancer Institute of the National Institutes of Health [U01-CA199277, P30-CA033572, P30-CA023100, UM1-CA164917, R01-CA077398]
- California Department of Public Health [103885]
- Centers for Disease Control and Prevention [5NU58DP006344]
- National Cancer Institute's Surveillance, Epidemiology and End Results Program [HHSN261201800032I]
- Against Breast Cancer Registered Charity [1121258]
- NCRN
- European Commission (DG-SANCO)
- International Agency for Research on Cancer
- Ligue Contre le Cancer (France)
- Institut Gustave Roussy (France)
- Mutuelle Generale de l'Education Nationale (France)
- Institut National de la Sante et de la Recherche Medicale (INSERM) (France)
- German Cancer Aid (Germany)
- German Cancer Research Center (DKFZ) (Germany)
- Federal Ministry of Education and Research (BMBF) (Germany)
- Hellenic Health Foundation (Greece)
- Stavros Niarchos Foundation (Greece)
- Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy (Italy)
- National Research Council (Italy)
- Dutch Ministry of Public Health, Welfare and Sports (VWS) (The Netherlands)
- Netherlands Cancer Registry (NKR) (The Netherlands)
- LK Research Funds (The Netherlands)
- Dutch Prevention Funds (The Netherlands)
- Dutch ZON (Zorg Onderzoek Nederland) (The Netherlands)
- World Cancer Research Fund (WCRF) (The Netherlands)
- Statistics Netherlands (The Netherlands)
- Health Research Fund (FIS) (Spain) [PI13/00061, PI13/01162]
- Regional Government of Andalucia (Spain)
- Regional Government of Asturias (Spain)
- Regional Government of Basque Country (Spain)
- Regional Government of Murcia (Spain)
- Regional Government of Navarra (Spain)
- ISCIII RETIC (Spain) [RD06/0020]
- Cancer Research UK (United Kingdom) [14136, C570/A16491, C8221/A19170]
- Medical Research Council (United Kingdom) [1000143, MR/M012190/1]
- Baden Wurttemberg Ministry of Science, Research and Arts
- German Cancer Aid (Deutsche Krebshilfe)
- NIHR [PGfAR 0707-10031]
- NIHR Manchester Biomedical Research Centre [IS-BRC1215-20007]
- German Cancer Aid [110837, 70114178]
- Federal Ministry of Education and Research, Germany [01GY1901]
- European Regional Development Fund
- Free State of Saxony, Germany [713-241202, 14505/2470, 14575/2470]
- Federal Ministry of Education and Research (BMBF) Germany [01KW9975/5, 01KW9976/8, 01KW9977/0, 01KW0114, 01KH0402]
- Robert Bosch Foundation, Stuttgart
- Deutsches Krebsforschungszentrum (DKFZ), Heidelberg
- Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum
- Department of Internal Medicine, Johanniter GmbH Bonn, Johanniter Krankenhaus, Bonn, Germany
- Deutsche Krebshilfe e. V. [70492, 70-2892-BR I, 106332, 108253, 108419, 110826, 110828]
- Claudia von Schilling Foundation for Breast Cancer Research
- Lower Saxonian Cancer Society
- Rudolf Bartling Foundation
- Helsinki University Hospital Research Fund
- Sigrid Juselius Foundation
- Cancer Foundation Finland
- Friends of Hannover Medical School
- German Federal Ministry of Research and Education [RUS08/017]
- Russian Foundation for Basic Research [17-44-020498, 17-29-06014]
- Ministry of Science and Higher Education of the Russian Federation [AAAA-A16-116020350032-1]
- KARBAC
- Stockholm County Council
- Karolinska Institutet
- The Gustav V Jubilee foundation
- Bert von Kantzows foundation
- Marit and Hans Rausings Initiative Against Breast Cancer
- special Government Funding (VTR) of Kuopio University Hospital grants
- Cancer Fund of North Savo
- Finnish Cancer Organizations
- University of Eastern Finland
- Stichting tegen Kanker
- FWO
- Research Centre for Genetic Engineering and Biotechnology Georgi D. Efremov, MASA
- Hamburg Cancer Society
- Italian Association for Cancer Research (AIRC)
- NIH grants [U19 CA148065, R01CA100374, R35CA253187, R01CA192393, R01CA116167, R01CA176785, CA63464, CA54281, CA098758, CA132839, CA164973, CA97396, CA128931, CA116201, CA140286, CA177150, P01 CA87969, UM1 CA186107, UM1 CA176726]
- NIH Specialized Program of Research Excellence (SPORE) in Breast Cancer [P50CA116201]
- VicHealth
- Cancer Council Victoria
- Australian National Health and Medical Research Council [209057, 396414, 1074383]
- Swedish Cancer Society
- Swedish Research Council
- Local hospital funds
- Berta Kamprad Foundation
- Robert and Kate Niehaus Clinical Cancer Genetics Initiative
- Canadian Institutes of Health Research for the CIHR Team in Familial Risks of Breast Cancer program [CRN-87521]
- Ministry of Economic Development, Innovation and Export Trade [PSR-SIIRI-701]
- K.G. Jebsen Centre for Breast Cancer Research
- Research Council of Norway [193387/V50, 193387/H10]
- South Eastern Norway Health Authority [39346]
- Norwegian Cancer Society
- USA National Cancer Institute of the National Institutes of Health [U01CA164920]
- Komen Foundation
- North Carolina University Cancer Research Fund
- Biobanking and Biomolecular Resources Research Infrastructure [BBMRI-NL CP16]
- Intramural Research Funds of the National Cancer Institute, Department of Health and Human Services, USA
- Intramural Research Program of the National Institutes of Health, NCI, Division of Cancer Epidemiology and Genetics
- Intramural Research Program of the Division of Cancer Epidemiology and Genetics
- Division of Cancer Prevention, National Cancer Institute, National Institutes of Health
- Breast Cancer Campaign [2010PR62, 2013PR044]
- Sheffield Experimental Cancer Medicine Centre
- Breast Cancer Now Tissue Bank
- UK National Institute for Health Research Biomedical Research Centre at the University of Cambridge
- Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [Z01-ES049033, Z01-ES044005, Z01-ES102245]
- Susan G. Komen for the Cure [FAS0703856]
- DKFZ
- Swedish Cancer Foundation
- Swedish Research Council [VR 2017-00644]
- program of the Minister of Science and Higher Education [002/RID/2018/19]
- Specialized Program of Research Excellence (SPORE) in Breast Cancer [CA116201]
- National Cancer Institute (NCI) grant [R01 CA163353]
- Women's Cancer Center at the Huntsman Cancer Institute (HCI)
- Utah Population Database (UPDB)
- Utah Cancer Registry (UCR)
- HCI (Huntsman Cancer Foundation)
- University of Utah program in Personalized Health and Center for Clinical and Translational Science
- NCI [P30 CA42014]
- NCI's SEER Program [HHSN261201800016I]
- US Center for Disease Control and Prevention's National Program of Cancer Registries [NU58DP0063200]
- University of Utah
- Huntsman Cancer Foundation
- Lon V Smith Foundation [LVS39420]
- Institute of Cancer Research (ICR), London
- The Eve Appeal (The Oak Foundation)
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
- National Institute for Health Research [NIHR202411]
- Cancer Research UK programme grant (the Integrative Cancer Epidemiology Programme) [C18281/A19169]
- NIHR Bristol Biomedical Research Centre - NIHR
- Medical Research Council [MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, MC_UU_00011/4]
- University of Bristol
- Victorian Cancer Agency [MCRF-18005]
- [PSRSIIRI-701]
- [HHSN261201800015I]
- [HHSN261201800009I]
- [ERC-2011-294576]
- [P30 CA68485]
- [PBZ_KBN_122/P05/2004]
The study provides strong evidence that higher overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce the risk of breast cancer. The adoption of active lifestyles may help reduce the burden of the most common cancer in women.
Objectives Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics. Methods We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (n(snps)=5) or sedentary time (n(snps)=6), or accelerometer-measured (n(snps)=1) or self-reported (n(snps)=5) vigorous physical activity. Results Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;similar to 8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,>= 3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (similar to 7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger). Conclusion Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer risk. More widespread adoption of active lifestyles may reduce the burden from the most common cancer in women.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据