期刊
BRITISH JOURNAL OF OPHTHALMOLOGY
卷 -, 期 -, 页码 -出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/bjo-2022-321277
关键词
imaging; retina; choroid; glaucoma; macula
资金
- High-level Hospital Construction Project, Zhongshan Ophthalmic Center, Sun Yat-sen University [303020104]
- National Natural Science Foundation of China [82070955, 82000901]
- Science and Technology Programme of Guangzhou, China
- Research to Prevent Blindness (New York, NY)
- National Eye Institute [EY029058]
This study explores the relationship between choriocapillaris flow deficit percentage (FD%) and ganglion cell-inner plexiform layer (GCIPL) thickness in a non-glaucomatous population. The results show a significant correlation between CC FD% and GCIPL thickness, which could provide insights on the development and progression of glaucoma.
Aims To explore the relationship between choriocapillaris (CC) flow deficit percentage (FD%) and ganglion cell-inner plexiform layer (GCIPL) thickness in a population-based sample of non-glaucomatous eyes. Methods This is a longitudinal cohort study and prospective cross-sectional study. Non-glaucoma Chinese subjects aged 18 years or older were enrolled. All participants underwent a detailed ophthalmic examination, including swept-source optical coherence tomography (SS-OCT) and SS-OCT angiography. Average, inner average, outer average and nine Early Treatment Diabetic Retinopathy Study sub-regions of GCIPL thickness and CC FD% were measured. The correlation between CC FD% and GCIPL was assessed using a linear regression model, and the relationship between the rate of change of GCIPL thickness and CC FD% was further validated in a 2year longitudinal study. Results In the cross-sectional study including 3514 participants (3514 non-glaucoma eyes), a higher CC FD% was significantly associated with a thinner GCIPL (beta=-0.32; 95% CI -0.43 to -0.21; p<0.001). Further, in a longitudinal study (453 eyes of 453 participants), a faster increase in CC FD% was found to be significantly associated with a faster decrease in GCIPL thickness (beta=-0.10; 95% CI -0.17 to -0.03; p=0.004) after adjusting for age, sex, axial length and image quality score. Conclusions This is the first time to show that CC FD% and GCIPL thickness were correlated in both cross-sectional and longitudinal studies of non-glaucomatous individuals, which may potentially provide further insights on the role of CC perfusion in glaucoma development and progression.
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