4.6 Article

Unmanipulated haploidentical haematopoietic cell transplantation with radiation-free conditioning in Fanconi anaemia: A retrospective analysis from the Chinese Blood and Marrow Transplantation Registry Group

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

The Incidence, Outcomes, and Risk Factors of Secondary Poor Graft Function in Haploidentical Hematopoietic Stem Cell Transplantation for Acquired Aplastic Anemia

Fan Lin et al.

Summary: Secondary poor graft function (sPGF) after haploidentical hematopoietic stem cell transplantation (HSCT) in patients with acquired aplastic anemia (AA) has a cumulative incidence of 4.62% and is associated with lower 2-year overall survival. Later neutrophil engraftment and a history of refractory cytomegalovirus viremia are risk factors for sPGF.

FRONTIERS IN IMMUNOLOGY (2022)

Article Hematology

Transplantation for Fanconi anaemia: lessons learned from Brazil

Carmem Bonfim et al.

Lancet Haematology (2022)

Article Biophysics

Survival and toxicity outcomes of hematopoietic stem cell transplantation for pediatric patients with Fanconi anemia: a unified multicentric national study from the Spanish Working Group for Bone Marrow Transplantation in Children

L. Murillo-Sanjuan et al.

Summary: Hematopoietic stem cell transplantation (HSCT) is an effective curative option for hematological manifestations in Fanconi anemia (FA) patients, with a high success rate and overall survival of 73% at 5 years post-transplant. However, patients with myelodysplastic syndrome (MDS) have a lower survival rate compared to those with bone marrow failure (BMF).

BONE MARROW TRANSPLANTATION (2021)

Article Surgery

The incidence, clinical outcome, and protective factors of mixed chimerism following hematopoietic stem cell transplantation for severe aplastic anemia

Zheng-Li Xu et al.

Summary: The study showed that the incidence of MC was significantly lower in HID transplants, and MC was associated with lower levels of CD3 + cells, lower rates of II-IV aGvHD, higher rates of secondary graft rejection, and poorer overall survival.

CLINICAL TRANSPLANTATION (2021)

Article Hematology

Impaired T- and NK-cell reconstitution after haploidentical HCT with posttransplant cyclophosphamide

Benedetta Rambaldi et al.

Summary: Administration of posttransplant cyclophosphamide has increased the number of patients undergoing HLA-haploidentical hematopoietic cell transplantation. Immune reconstitution in haplo-HCT patients showed delayed T-cell recovery skewed towards effector memory T cells and higher regulatory T cell ratios early after transplant. NK cell reconstitution also differed, with increased immature NK cells and enrichment of specific NK cell metadusters after haplo-HCT.

BLOOD ADVANCES (2021)

Article Hematology

Haplo-identical or mismatched unrelated donor hematopoietic cell transplantation for Fanconi anemia: Results from the Severe Aplastic Anemia Working Party of the EBMT

Josune Zubicaray et al.

Summary: Allogeneic hematopoietic cell transplantation is the only cure for Fanconi anemia (FA), but alternative donors like haplo-identical donors may offer better outcomes. Transplantation with haplo-identical donors with only in vivo T cell depletion may lead to better event-free survival (EFS) for FA patients.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

Article Hematology

HLA-haploidentical TCRαβ+/CD19+-depleted stem cell transplantation in children and young adults with Fanconi anemia

Luisa Strocchio et al.

Summary: The use of HLA-haploidentical T-cell receptor and CD19(+) cell-depleted hematopoietic stem cell transplantation for Fanconi anemia patients resulted in high success rates, low incidences of acute and chronic graft-versus-host disease, and good overall survival rates.

BLOOD ADVANCES (2021)

Article Hematology

Excellent overall and chronic graft-versus-host-disease-free event-free survival in Fanconi anaemia patients undergoing matched related- and unrelated-donor bone marrow transplantation using alemtuzumab-Flu-Cy: the UK experience

Fanette Bernard et al.

Summary: The study revealed that matched related or unrelated haematopoietic stem cell transplantation has excellent outcomes in children with Fanconi anaemia, with factors such as bone marrow status, source of stem cells, and immunosuppressive therapy significantly impacting overall survival. Other factors like cytomegalovirus serostatus and specific treatment regimens also played a role in patient outcomes.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

Review Oncology

The consensus from The Chinese Society of Hematology on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation: 2021 update

Xiao-hui Zhang et al.

Summary: The recent updated consensus recommendations from The Chinese Society of Hematology on allogeneic hematopoietic stem cell transplantation (allo-HSCT) include a new donor selection algorithm, encouraging salvage treatment with novel immunotherapies, and reflecting additional evidence for specific patient groups in transplantation application.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Hematology

Increased Infections and Delayed CD4+ T Cell but Faster B Cell Immune Reconstitution after Post-Transplantation Cyclophosphamide Compared to Conventional GVHD Prophylaxis in Allogeneic Transplantation

Farhad Khimani et al.

Summary: PTCy-based GVHD prophylaxis is associated with delayed CD4+ T cell but faster B cell immune reconstitution, and a higher frequency of infections compared with conventional GVHD prophylaxis. However, it has no impact on nonrelapse mortality or overall survival in adult patients undergoing allo-HCT.

TRANSPLANTATION AND CELLULAR THERAPY (2021)

Review Hematology

How I manage patients with Fanconi anaemia

Carlo Dufour

BRITISH JOURNAL OF HAEMATOLOGY (2017)

Review Hematology

How I treat MDS and AML in Fanconi anemia

Regis Peffault de Latour et al.

Article Biophysics

Successful haploidentical bone marrow transplantation in Fanconi anemia

R Elhasid et al.

BONE MARROW TRANSPLANTATION (2000)