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Article
Multidisciplinary Sciences
Raquel Viana et al.
Summary: The SARS-CoV-2 epidemic in southern Africa has experienced three distinct waves, driven by different variants. The recently identified Omicron variant has rapidly spread in South Africa and to numerous countries, raising global concern.
Article
Microbiology
Ana Valesca Fernandes Gilson Silva et al.
Summary: This study conducted epidemiological monitoring using diverse strategies to describe the initial stages of the COVID-19 pandemic in Betim City, Brazil. The results revealed the prevalence of the virus, risk factors for positivity, and multiple viral introductions.
FRONTIERS IN MICROBIOLOGY
(2022)
Letter
Infectious Diseases
Yosuke Hirotsu et al.
JOURNAL OF INFECTION
(2022)
Article
Biochemistry & Molecular Biology
Andrea Brizzi et al.
Summary: Analysis of individual-level patient records from Brazil reveals that COVID-19 mortality rates are significantly influenced by pre-pandemic geographic inequities and healthcare capacity during the pandemic. The study also documents the temporary shocks in hospital fatality rates following the spread of the Gamma variant in 14 state capitals, where more than half of hospitalized patients aged 70 years and older died. The fluctuations in Brazil's COVID-19 in-hospital fatality rates were primarily associated with geographic inequities and shortages in healthcare capacity. Approximately half of the COVID-19 deaths in hospitals in the 14 cities could have been avoided without pre-pandemic geographic inequities and healthcare pressure. Investments in healthcare resources, healthcare optimization, and pandemic preparedness are critical to minimize the impact of highly transmissible and deadly pathogens like SARS-CoV-2, especially in low- and middle-income countries.
Article
Multidisciplinary Sciences
Paul Elliott et al.
Summary: The rapid transmission of the Omicron variant of SARS-CoV-2 has caused a surge in cases worldwide, including in England. The prevalence of infection is increasing, particularly among older age groups, but hospitalizations and deaths remain lower compared to previous waves, likely due to high levels of vaccination.
Article
Virology
Joice P. Silva et al.
Summary: A national epidemiological surveillance program was conducted in Brazil from April to October 2021 to monitor the dynamics and dissemination of COVID-19 VOCs. The study found that Delta VOC was first detected in June 2021 and replaced Gamma VOC within sixteen weeks. Furthermore, it was found that Delta VOC has a higher transmission rate than Gamma VOC and individuals infected with Delta VOC exhibit different symptom presentations.
Article
Virology
Lulan Wang et al.
Summary: The study provides evidence of intervariant and intravariant recombination of rapidly evolving SARS-CoV-2 genomes, suggesting potential for more infectious, immune-escaping, and disease-causing Omicron and Delta-Omicron variants.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joseph A. Lewnard et al.
Summary: Comparison of outcomes of SARS-CoV-2 Delta and Omicron infections reveals reduced severity of Omicron infections, especially in unvaccinated individuals. There is no differential risk of severe outcomes between subvariants BA.1 and BA.2. Continual assessment of clinical outcomes associated with SARS-CoV-2 variants is crucial for medical interventions and healthcare resource management.
Article
Virology
Luiz Carlos Junior Alcantara et al.
Summary: Brazil has experienced a COVID-19 epidemic with the circulation of multiple SARS-CoV-2 variants, some of which have led to a rapid increase in cases and deaths. Strengthening genomic efforts and continuing vaccination remain crucial due to the emergence of variants that evade neutralizing antibody response.
Article
Virology
Paula L. C. Fonseca et al.
Summary: The emergence and spread of the Delta variant in the state of Minas Gerais, Brazil, was monitored through genotyping and genome sequencing. The Delta variant accounted for 70% of cases after 8 weeks and showed higher transmissibility compared to the Gamma variant. The dominance of the Delta variant did not result in an increase in cases and deaths, indicating that vaccination may have played a role in restraining the epidemic growth.
Article
Virology
Marta Giovanetti et al.
Summary: The COVID-19 epidemic in Brazil was initially driven by the Gamma variant, but was later replaced by the Delta variant. Unlike in other countries, the rapid spread of Delta in Brazil did not lead to a significant increase in cases and deaths, which may be attributed to the combination of early vaccination campaign and natural immunity from prior infection with the Gamma variant. The study highlights the importance of strengthening genomic monitoring on a national level to detect the emergence and spread of other variants of concern.
Article
Biochemistry & Molecular Biology
Marcia C. Castro et al.
Summary: Brazil has been heavily impacted by COVID-19, with a significant increase in deaths in 2020 and 2021, leading to a decline in life expectancy and mortality levels not seen since 20 years ago.
Editorial Material
Virology
Filipe R. R. Moreira et al.
Article
Virology
Aine O'Toole et al.
Summary: The global virus genomics community has responded unprecedentedly to the SARS-CoV-2 pandemic, leading to significant advances in 'real-time' generation and sharing of genomic data. The development of new analytical methods, such as pangolin, has been necessary to handle the rapid growth in virus genome data production. Pangolin has processed nearly two million virus genomes, aiding in SARS-CoV-2 genomic epidemiology and providing researchers with valuable information about the pandemic's transmission lineages.
Article
Biochemistry & Molecular Biology
Bui Quang Minh et al.
MOLECULAR BIOLOGY AND EVOLUTION
(2020)
Article
Multidisciplinary Sciences
Darlan S. Candido et al.
Article
Immunology
Joilson Xavier et al.
EMERGING MICROBES & INFECTIONS
(2020)
