COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis

Article Immunology

IL-1 reprogramming of adult neural stem cells limits neurocognitive recovery after viral encephalitis by maintaining a proinflammatory state

Allison L. Soung et al.

Summary: In viral encephalitis, continued astrocyte inflammasome-mediated production of IL-113 is maintained by IL-1R1 signaling in neural stem cells, preventing synapse repair and promoting spatial learning deficits.

BRAIN BEHAVIOR AND IMMUNITY (2022)

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Letter Medicine, General & Internal

Long-term neuropsychiatric outcomes in COVID-19 survivors: A 1-year longitudinal study

Raul Mendez et al.

JOURNAL OF INTERNAL MEDICINE (2022)

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Article Immunology

Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients

Mathilde Bellon et al.

Summary: This study analyzed the cerebrospinal fluid features of 31 COVID-19 patients with neurological complications and found no SARS-CoV-2 RNA or intrathecal IgG synthesis, but observed signs of blood-brain barrier disruption. These results may help improve understanding of SARS-CoV-2 related neuropathogenesis.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Allergy

Anakinra combined with methylprednisolone in patients with severe COVID-19 pneumonia and hyperinflammation: An observational cohort study

Giorgio Bozzi et al.

Summary: The study involving 120 COVID-19 patients showed that treatment with anakinra plus methylprednisolone could reduce the risk of death, especially in patients with hyperinflammation and respiratory failure. Randomized controlled trials are needed to confirm these findings.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Neurosciences

Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19

Abhishek Jaywant et al.

Summary: Most COVID-19 patients who require acute rehabilitation prior to discharge exhibit cognitive impairment, with deficits commonly seen in working memory, set-shifting, divided attention, and processing speed. Interventions targeting attention and executive dysfunctions may be beneficial for this population.

NEUROPSYCHOPHARMACOLOGY (2021)

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Article Virology

High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster

Julia R. Port et al.

Summary: This study demonstrates the detrimental impact of a continuous high-fat high-sugar diet on COVID-19 outcome in a Syrian hamster model. The findings support the use of the hamster model for testing restrictive diets and immunomodulatory therapies to mitigate the adverse effects of metabolic disease on COVID-19.

VIRUSES-BASEL (2021)

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Article Clinical Neurology

COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital

Kiran T. Thakur et al.

Summary: Many patients with SARS-CoV-2 infection exhibit neurological signs and symptoms, but autopsy results show that most brains have low levels of detectable virus and it does not correlate with the histopathological alterations.

BRAIN (2021)

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Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

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Review Clinical Neurology

Neuropathological findings from COVID-19 patients with neurological symptoms argue against a direct brain invasion of SARS-CoV-2: A critical systematic review

Giuseppe Cosentino et al.

Summary: Neuropathological studies in COVID-19 patients reveal that neurological symptoms are associated with brain inflammatory reactions and hypoxic-ischemic damage rather than neuronal viral load. Older individuals are more likely to experience neurological symptoms.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

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Article Cell Biology

A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters

Traci L. Bricker et al.

Summary: The study found that intranasal administration provides superior protection against SARS-CoV-2 infection and inflammation in the upper respiratory tract compared to intramuscular injection, reducing weight loss, viral infection, and lung pathology. Therefore, intranasal delivery of ChAd-SARS-CoV-2-S candidate vaccine is supported for preventing SARS-CoV-2 infection.

CELL REPORTS (2021)

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Article Biology