期刊
BMC VETERINARY RESEARCH
卷 18, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12917-022-03474-3
关键词
Diarrhea; Inoculum dose; Experimental infection; Enterotoxigenic Escherichia coli; F4 fimbriae; Genetic marker; Piglet; Post-weaning
资金
- Innovation fund Denmark (IFD) [7076-00038B]
Host genotype plays a crucial role in the susceptibility to enterotoxigenic E. coli (ETEC), with CHCF1 genotype possibly corresponding to susceptibility towards ETEC F4ac/ab infection.
Host genotype is important for enterotoxigenic E. coli (ETEC) susceptibility. We conducted two trials to evaluate the effect of CHCF1 genotype on incidence of ETEC diarrhea. In trial 1 (n = 15 pigs), pigs were inoculated with 10(8) CFU or 10(10) CFU doses of an ETEC F4ac strain. In trial 2 (n = 33 pigs), pigs were inoculated with ETEC F4ab or F4ac. Across trials, all inoculated pigs that developed ETEC diarrhea were CHCF1 heterozygous susceptible (6/6). No inoculated CHCF1 homozygous resistant pigs developed ETEC diarrhea (0/26). Susceptibility towards ETEC F4ac/ab infection might correspond with CHCF1 genotype.
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