期刊
BMC NEUROLOGY
卷 22, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12883-022-02891-z
关键词
Lymphocytic hypophysitis; Autoimmune hypophysitis; Autoimmune hypothalamitis; Cognitive dysfunction; Memory impairment
资金
- Zikei Institute of Psychiatry
Autoimmune hypothalamitis is a rare neuroendocrine disorder that may be associated with autoimmune hypophysitis, but it is uncertain if they are consecutive diseases. This case presents the development of autoimmune hypothalamitis after central diabetes insipidus, with partial improvement through treatment.
Background Autoimmune hypothalamitis is a very rare neuroendocrine disorder that causes central diabetes insipidus, headache, visual impairment, and sometimes cognitive impairment. Autoimmune hypothalamitis may occur in association with autoimmune hypophysitis, including lymphocytic hypophysitis, or in isolation. It is not known whether autoimmune hypothalamitis and autoimmune hypophysitis are consecutive diseases. Case presentation A 52-year-old woman developed autoimmune hypothalamitis 7 years after developing central diabetes insipidus due to lymphocytic hypophysitis, resulting in severe memory impairment. High-dose intravenous methylprednisolone therapy improved her cognitive function and decreased the size of the lesion. Conclusion This case presented a unique clinical course, with a long period of time between the onset of autoimmune hypopituitaritis and the development of autoimmune hypothalamitis.
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