4.7 Article

The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A

Johanna Stachelscheid et al.

Summary: TCL1A, a proto-oncogene, plays a crucial role in tumor initiation and development, particularly in lymphocytic leukemia and lymphoma. Although the regulatory mechanisms are not fully understood, recent advances in research could facilitate future interventions to disrupt its oncogenic actions.

CANCERS (2021)

Article Oncology

Inhibition of Cdc20 suppresses the metastasis in triple negative breast cancer (TNBC)

Christine Song et al.

Summary: The study discovered that Cdc20 is significantly upregulated in human TNBC, positively correlated with patient survival, and essential for tumor formation and metastasis in TNBC. Cdc20 deficiency in TNBC cell lines resulted in decreased cell growth and migration, while mitotic inhibitors showed potential for blocking cancer cell growth and invasion.

BREAST CANCER (2021)

Article Multidisciplinary Sciences

Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia

Johannes Bloehdorn et al.

Summary: Understanding the complex genomics of chronic lymphocytic leukemia (CLL) has revealed distinct molecular subtypes with different prognostic implications, involving activation of epithelial-mesenchymal-transition (EMT) programs and genomic instability. Targeting these molecular subclasses may lead to new treatment strategies for CLL.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

The PRIDE database and related tools and resources in 2019: improving support for quantification data

Yasset Perez-Riverol et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Multidisciplinary Sciences

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL

A. Schrader et al.

NATURE COMMUNICATIONS (2018)

Review Biochemistry & Molecular Biology

Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases

Matthias Schmidt et al.

MOLECULES (2017)

Article Multidisciplinary Sciences

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation

Luying Jia et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Non-coding recurrent mutations in chronic lymphocytic leukaemia

Xose S. Puente et al.

NATURE (2015)

Article Multidisciplinary Sciences

Mutations driving CLL and their evolution in progression and relapse

Dan A. Landau et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

NEK9 depletion induces catastrophic mitosis by impairment of mitotic checkpoint control and spindle dynamics

Yasuyuki Kaneta et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Biochemistry & Molecular Biology

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

Dan A. Landau et al.

Review Cell Biology

Evolution and Function of the Mitotic Checkpoint

Mathijs Vleugel et al.

DEVELOPMENTAL CELL (2012)

Article Biochemistry & Molecular Biology

Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C

Helene Labit et al.

EMBO JOURNAL (2012)

Article Multidisciplinary Sciences

Structure of the mitotic checkpoint complex

William C. H. Chao et al.

NATURE (2012)

Review Oncology

Molecular basis of CLL

Yuri Pekarsky et al.

SEMINARS IN CANCER BIOLOGY (2010)

Article Hematology

Resistance of mature T cells to oncogene transformation

Sebastian Newrzela et al.

Article Multidisciplinary Sciences

Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL

Yuri Pekarsky et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Cell Biology

MCM proteins: DNA damage, mutagenesis and repair

JM Bailis et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2004)

Article Biochemistry & Molecular Biology

Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins

D Auguin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Biochemistry & Molecular Biology

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

A Sancar et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2004)

Article Chemistry, Multidisciplinary

HADDOCK: A protein-protein docking approach based on biochemical or biophysical information

C Dominguez et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

Article Multidisciplinary Sciences

Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression

R Bichi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

The protooncogene TCL1 is an Akt kinase coactivator

J Laine et al.

MOLECULAR CELL (2000)