MDM2 inhibition augments GVL effect

In this issue of Blood, Ho et al(1) report that inhibition of mouse double minute 2 (MDM2) increases the potency of T-cell responses to acute myeloid leukemia (AML) and facilitates the graft-versus-leukemia (GVL) effect in murine models of allogeneic hematopoietic cell transplantation(allo-HCT).

Automated summary

In this study, it was found that inhibition of MDM2 enhances T-cell responses to AML and facilitates the GVL effect in murine models of allo-HCT.