期刊
BIOSENSORS & BIOELECTRONICS
卷 211, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2022.114367
关键词
Dopamine; Fully exposed Fe-Sites; Oligo-layer graphene; Electrochemical biosensor; Subnanometric catalysts
类别
资金
- National Natural Science Foundation of China [22074157]
In this study, a simple pyrolysis approach was proposed to construct an electrochemical biosensor for dopamine detection. The sensor exhibits favorable sensitivity and enzyme-level molecular identification ability in the selective detection of dopamine.
Neurotransmitter dopamine (DA) has been implicated in a variety of physiological and pathological processes, realizing its low detection limit and high sensitivity analysis is of great significance for early disease diagnosis. Herein, we propose a simple pyrolysis approach for dispersing Fe-sites onto the N-doped graphene support (denoted as Fe/N-GR) to construct an electrochemical biosensor for DA detection. The fully exposed Fe-sites guaranteed the well-defined active center for electrochemical oxidation of DA. The Fe/N-GR electrochemical biosensor achieves an ultra-low detection limit for DA of 27 pM with a linear range of 50 pM-15 nM. Specifically, the Fe/N-GR electrochemical biosensor exhibits favorable sensitivity and enzyme-level molecular identification ability in the selective detection of DA versus other typical redox-active interferents. What's more, the detection of dopamine in real human serum samples verifies the applicability of the developed sensor. Our results demonstrate a promising means of using fully exposed metal-site subnanometric catalysts for electrochemical sensing applications.
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