期刊
BIORESOURCE TECHNOLOGY
卷 364, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2022.128064
关键词
Circular bioeconomy; Acetate valorization; Renewable carbon source; Acetate metabolism; Bioconversion
资金
- Mid-Career Researcher Program [NRF-2021R1A2C2007841]
- Basic Research Laboratory Program (BRL) [NRF-2022R1A4A1021692]
- Korean National Research Foundation - Korean Ministry of Science, ICT and Future Planning
- Framework of International Cooperation Program [2021K2A9A2A1200020611]
Acetate, a major byproduct of bioconversion, has the potential to produce various high-value platform chemicals and biofuels, but yields and titers have not reached their maximum. Recombinant strain development and pathway regulation are suggested to overcome this limitation.
Acetate is a major byproduct of the bioconversion of the greenhouse gas carbon dioxide, pretreatment of lignocellulose biomass, and microbial fermentation. The utilization and valorization of acetate have been emphasized in transforming waste to clean energy and value-added platform chemicals, contributing to the development of a closed carbon loop toward a low-carbon circular bio-economy. Acetate has been used to produce several platform chemicals, including succinate, 3-hydroxypropionate, and itaconic acid, highlighting the potential of acetate to synthesize many biochemicals and biofuels. On the other hand, the yields and titers have not reached the theoretical maximum. Recently, recombinant strain development and pathway regulation have been suggested to overcome this limitation. This review provides insights into the important constraints limiting the yields and titers of the biochemical and metabolic pathways of bacteria capable of metabolizing acetate for acetate bioconversion. The current developments in recombinant strain engineering are also discussed.
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