相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Development of VU6019650: A Potent, Highly Selective, andSystemically Active Orthosteric Antagonist of the M5MuscarinicAcetylcholine Receptor for the Treatment of Opioid Use Disorder
Aaron T. Garrison et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
Discovery of a potent M5 antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists
Rory A. Capstick et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2022)
Examining the role of muscarinic M5 receptors in VTA cholinergic modulation of depressive-like and anxiety-related behaviors in rats
Eric J. Nunes et al.
NEUROPHARMACOLOGY (2020)
Acute Negative Allosteric Modulation of M5 Muscarinic Acetylcholine Receptors Inhibits Oxycodone Self-Administration and Cue-Induced Reactivity with No Effect on Antinociception
Robert W. Gould et al.
ACS CHEMICAL NEUROSCIENCE (2019)
The Muscarinic Acetylcholine Receptor M5: Therapeutic Implications and Allosteric Modulation
Aaron M. Bender et al.
ACS CHEMICAL NEUROSCIENCE (2019)
Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold
Aaron M. Bender et al.
ACS CHEMICAL NEUROSCIENCE (2018)
Muscarinic M5 receptors modulate ethanol seeking in rats
Alice E. Berizzi et al.
NEUROPSYCHOPHARMACOLOGY (2018)
Continued optimization of the M5 NAM ML375: Discovery of VU6008667,, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies
Kevin M. McGowan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypes
Alexander R. Geanes et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M5-Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe
Patrick R. Gentry et al.
CHEMMEDCHEM (2014)
Discovery of the First M5-Selective and CNS Penetrant Negative Allosteric Modulator (NAM) of a Muscarinic Acetylcholine Receptor: (S)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)
Patrick R. Gentry et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Structural Modifications to Tetrahydropyridine-3-carboxylate Esters en Route to the Discovery of M5-Preferring Muscarinic Receptor Orthosteric Antagonists
Guangrong Zheng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
De Novo Prediction of P-Glycoprotein-Mediated Efflux Liability for Druglike Compounds
Hakan Gunaydin et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
Structural Modifications that Alter the P-Glycoprotein Efflux Properties of Compounds
Stephen A. Hitchcock
JOURNAL OF MEDICINAL CHEMISTRY (2012)