4.7 Article

Discovery of 4-methyl-3-(pyridin-2-ylamino)benzamide derivatives as C-Abl inhibitors with potential neuroprotective effect

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Efficacy of Nilotinib in Patients With Moderately Advanced Parkinson Disease A Randomized Clinical Trial

Tanya Simuni et al.

Summary: This study aimed to evaluate the safety and tolerability of nilotinib in Parkinson disease patients, as well as its impact on various disease-related parameters. The results showed a negative trend in efficacy, low penetration of nilotinib in cerebrospinal fluid, and no alteration of dopamine metabolites levels, indicating that further testing of nilotinib for PD treatment is not recommended.

JAMA NEUROLOGY (2021)

Article Chemistry, Medicinal

Preparation and optimization of nilotinib self-micro-emulsifying drug delivery systems to enhance oral bioavailability

Ashok Zakkula et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2020)

Editorial Material Clinical Neurology

The Narrowing Path for Nilotinib and Other Potential Disease-Modifying Therapies for Parkinson Disease

Alberto J. Espay et al.

JAMA NEUROLOGY (2020)

Article Pharmacology & Pharmacy

Computational studies of potent covalent inhibitors on wild type or T790M/L858R mutant epidermal growth factor receptor

Zichao Yang et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Review Oncology

Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy

Federico Rossari et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Article Biochemistry & Molecular Biology

c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death

R. Wu et al.

CELL DEATH AND DIFFERENTIATION (2016)

Article Medicine, Research & Experimental

Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration

Saurav Brahmachari et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Review Biochemistry & Molecular Biology

The Capable ABL: What Is Its Biological Function?

Jean Y. J. Wang

MOLECULAR AND CELLULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease

Senthilkumar S. Karuppagounder et al.

SCIENTIFIC REPORTS (2014)

Editorial Material Biochemistry & Molecular Biology

c-Abl tyrosine kinase in the DNA damage response: cell death and more

V. Meltser et al.

CELL DEATH AND DIFFERENTIATION (2011)

Article Clinical Neurology

C-Abl Tyrosine Kinase Signaling: A New Player in AD Tau Pathology

L. D. Estrada et al.

Current Alzheimer Research (2011)

Article Biochemistry & Molecular Biology

c-Abl in Neurodegenerative Disease

Sarah D. Schlatterer et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2011)

Article Chemistry, Multidisciplinary

Fast and Accurate Predictions of Binding Free Energies Using MM-PBSA and MM-GBSA

Giulio Rastelli et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2010)

Article Multidisciplinary Sciences

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

Han Seok Ko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Improved side-chain torsion potentials for the Amber ff99SB protein force field

Kresten Lindorff-Larsen et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2010)

Article Chemistry, Medicinal

Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

Richard A. Friesner et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Article Chemistry, Medicinal

Novel procedure for modeling ligand/receptor induced fit effects

W Sherman et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Review Chemistry, Multidisciplinary

Integrated modeling program, applied chemical theory (IMPACT)

JL Banks et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)

Article Neurosciences

Integrin-mediated dendrite branch maintenance requires Abelson (Ab1) family kinases

EMY Moresco et al.

JOURNAL OF NEUROSCIENCE (2005)

Article Chemistry, Multidisciplinary

Development and testing of a general amber force field

JM Wang et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Review Cell Biology

Regulation of the C-Abl and Bcr-Abl tyrosine kinases

O Hantschel et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)

Review Chemistry, Multidisciplinary

Calculating structures and free energies of complex molecules: Combining molecular mechanics and continuum models

PA Kollman et al.

ACCOUNTS OF CHEMICAL RESEARCH (2000)