相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Implications of statin metabolism-related gene testing in guiding individualized drug use in cardiovascular diseases
Yiliang Zhang et al.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH (2023)
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo
Aldo Peschiulli et al.
ACS MEDICINAL CHEMISTRY LETTERS (2022)
Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
Ju-Hyun Lee et al.
NATURE NEUROSCIENCE (2022)
Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR)
Joao P. S. Ferreira et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Design, Synthesis and Evaluation of 2,4,6-substituted Pyrimidine Derivatives as BACE-1 inhibitor: Plausible Lead for Alzheimer's Disease
Priti Jain et al.
MEDICINAL CHEMISTRY (2021)
Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial
Yuji Koriyama et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease
Yash Pal Singh et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer's disease
Lailiang Qu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Iron and Ferroptosis as Therapeutic Targets in Alzheimer's Disease
Andrew Gleason et al.
NEUROTHERAPEUTICS (2021)
Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology
Scott Ayton et al.
MOLECULAR PSYCHIATRY (2020)
BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease
Nour M. Moussa-Pacha et al.
MEDICINAL RESEARCH REVIEWS (2020)
Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2
Liping H. Pettus et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints
Leonard L. Winneroski et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2020)
Recent Studies on Design and Development of Drugs Against Alzheimer's Disease (AD) Based on Inhibition of BACE-1 and Other AD-causative Agents
Satya P. Gupta et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2020)
Biological Evaluation of Newly Synthesized Biaryl Guanidine Derivatives to Arrest β-Secretase Enzymatic Activity Involved in Alzheimer's Disease
Sayyad Ali et al.
BIOMED RESEARCH INTERNATIONAL (2020)
Advances in Studies on Neurodegenerative Diseases and their Treatments
Satya P. Gupta
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2020)
Lead discovery of a guanidinyl tryptophan derivative on amyloid cascade inhibition
Piyapan Suwanttananuruk et al.
OPEN CHEMISTRY (2020)
Multi-target inhibitors against Alzheimer disease derived from 3-hydrazinyl 1,2,4-triazine scaffold containing pendant phenoxy methyl-1,2,3-triazole: Design, synthesis and biological evaluation
Mahnaz Yazdani et al.
BIOORGANIC CHEMISTRY (2019)
Does Intraneuronal Accumulation of Carboxyl-terminal Fragments of the Amyloid Precursor Protein Trigger Early Neurotoxicity in Alzheimer's Disease?
L. Lauritzen et al.
CURRENT ALZHEIMER RESEARCH (2019)
Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2
Kazuki Fujimoto et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads
Daniel Oehlrich et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
Management of oxidative stress and other pathologies in Alzheimer's disease
Miriama Simunkova et al.
ARCHIVES OF TOXICOLOGY (2019)
Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors
Yu-Chen Yen et al.
BIOCHEMISTRY (2019)
Trifluoromethyl Dihydrothiazine-Based β-Secretase (BACE1) Inhibitors with Robust Central β-Amyloid Reduction and Minimal Covalent Binding Burden
Kosuke Anan et al.
CHEMMEDCHEM (2019)
New evolutions in the BACE1 inhibitor field from 2014 to 2018
Chien-Chi Hsiao et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
Piyoosh Sharma et al.
PROGRESS IN NEUROBIOLOGY (2019)
BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease
Miguel A. Maia et al.
PHARMACEUTICALS (2019)
Risk factors for Alzheimer's disease
Richard A. Armstrong
FOLIA NEUROPATHOLOGICA (2019)
Alzheimer's disease
C. A. Lane et al.
EUROPEAN JOURNAL OF NEUROLOGY (2018)
Synthesis and structure-activity relationship study of multi-target triazine derivatives as innovative candidates for treatment of Alzheimer's disease
Aida Iraji et al.
BIOORGANIC CHEMISTRY (2018)
Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity
Patrik Johansson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice
WonHee Kim et al.
MOLECULAR NEURODEGENERATION (2018)
Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease
K. Rajasekhar et al.
RSC ADVANCES (2018)
The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease
Ulf Neumann et al.
EMBO MOLECULAR MEDICINE (2018)
Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer's disease: randomized, double-blind, placebo-controlled study
Maarten Timmers et al.
ALZHEIMERS RESEARCH & THERAPY (2018)
The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases
Saima Kausar et al.
CELLS (2018)
2-Substituted-thio-N-(4-substituted-thiazo1/1H-imidazol-2-yl) acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies
Gang Yan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Streptococcus pyogenes quinolinate-salvage pathway-structural and functional studies of quinolinate phosphoribosyl transferase and NH3-dependent NAD+ synthetase
William T. Booth et al.
FEBS JOURNAL (2017)
Role of Glutamate and NMDA Receptors in Alzheimer's Disease
Rui Wang et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
BACE inhibition-dependent repair of Alzheimer's pathophysiology
Aylin D. Keskin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport
Nadine Ruderisch et al.
EBIOMEDICINE (2017)
Role of BACE1 in Alzheimer's synaptic function
Brati Das et al.
TRANSLATIONAL NEURODEGENERATION (2017)
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Brent R. Stockwell et al.
CELL (2017)
Synthesis and biological evaluation of quinazolinone-based hydrazones with potential use in Alzheimer's disease
Zahra Haghighijoo et al.
BIOORGANIC CHEMISTRY (2017)
Towards an understanding of amyloid-β oligomers: characterization, toxicity mechanisms, and inhibitors
Shin Jung C. Lee et al.
CHEMICAL SOCIETY REVIEWS (2017)
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria
Bruno Dubois et al.
ALZHEIMERS & DEMENTIA (2016)
Rational design, synthesis and in vitro evaluation of allylidene hydrazinecarboximidamide derivatives as BACE-1 inhibitors
Priti Jain et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Synthesis of (3S,4S)-4-aminopyrrolidine-3-ol derivatives and biological evaluation for their BACE1 inhibitory activities
Quang De Tran et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Alzheimer's therapy targeting the β-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies
Masuo Ohno
BRAIN RESEARCH BULLETIN (2016)
Asp32 and Asp228 determine the selective inhibition of BACE1 as shown by docking and molecular dynamics simulations
Maricarmen Hernandez-Rodriguez et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates
Mihirbaran Mandal et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase
John B. Jordan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease
Jack D. Scott et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Gamma Secretase Modulators: New Alzheimer's Drugs on the Horizon?
Matthew G. Bursavich et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System
Kathryn M. Munro et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2016)
Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons
Martina Pigoni et al.
MOLECULAR NEURODEGENERATION (2016)
The antibody aducanumab reduces Aβ plaques in Alzheimer's disease
Jeff Sevigny et al.
NATURE (2016)
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients
Matthew E. Kennedy et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
BACE1 Physiolocical Functions May Limit Its Use as Therapeutic Tarcet for Alzneimer's Disease
Soraia Barao et al.
TRENDS IN NEUROSCIENCES (2016)
Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein
Saoussen Ben Halima et al.
CELL REPORTS (2016)
Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)
Kenneth M. Boy et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease
Jian Jeffrey Chen et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design
Christopher R. Butler et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors
Michael A. Brodney et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans
Patrick C. May et al.
JOURNAL OF NEUROSCIENCE (2015)
A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice
Ulf Neumann et al.
MOLECULAR NEURODEGENERATION (2015)
Oxidative stress: a concept in redox biology and medicine
Helmut Sies
REDOX BIOLOGY (2015)
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors
Federica Prati et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Metal Ions and Intrinsically Disordered Proteins and Peptides: From Cu/Zn Amyloid-β to General Principles
Peter Faller et al.
ACCOUNTS OF CHEMICAL RESEARCH (2014)
Sex Modifies the APOE-Related Risk of Developing Alzheimer Disease
Andre Altmann et al.
ANNALS OF NEUROLOGY (2014)
The evolution of amidine-based brain penetrant BACE1 inhibitors
Daniel Oehlrich et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Discovery of potent iminoheterocycle BACE1 inhibitors
John P. Caldwell et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
BACE1 (beta-secretase) inhibitors for the treatment of Alzheimer's disease
Arun K. Ghosh et al.
CHEMICAL SOCIETY REVIEWS (2014)
Discovery of 7-Tetrahydropyran-2-yl Chromans: β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) inhibitors That Reduce Amyloid β-Protein (Aβ) in the Central Nervous System
Allen A. Thomas et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
Robert Vassar et al.
JOURNAL OF NEUROCHEMISTRY (2014)
BACE1 activity regulates cell surface contactin-2 levels
Vivek Gautam et al.
MOLECULAR NEURODEGENERATION (2014)
Microglial priming in neurodegenerative disease
V. Hugh Perry et al.
NATURE REVIEWS NEUROLOGY (2014)
Amino Acid Sequence and Structural Comparison of BACE1 and BACE2 Using Evolutionary Trace Method
Hoda Mirsafian et al.
SCIENTIFIC WORLD JOURNAL (2014)
BACE1 inhibitor drugs in clinical trials for Alzheimer's disease
Robert Vassar
ALZHEIMERS RESEARCH & THERAPY (2014)
Alzheimer's disease drug-development pipeline: few candidates, frequent failures
Jeffrey L. Cummings et al.
ALZHEIMERS RESEARCH & THERAPY (2014)
The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques
Patty C. Kandalepas et al.
ACTA NEUROPATHOLOGICA (2013)
A review on cholinesterase inhibitors for Alzheimer's disease
Preet Anand et al.
ARCHIVES OF PHARMACAL RESEARCH (2013)
Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring
Shuji Yonezawa et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
BACE2 as a new diabetes target: a patent review (2010-2012)
Christopher Southan
EXPERT OPINION ON THERAPEUTIC PATENTS (2013)
Spirocyclic beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid beta in a Higher Species
Kevin W. Hunt et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Structure-Based Design of β-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer's Disease
Jing Yuan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Virtual Screening and Structure-Based Discovery of Indole Acylguanidines as Potent β-secretase (BACE1) Inhibitors
Yiquan Zou et al.
MOLECULES (2013)
BACE1 Regulates Hippocampal Astrogenesis via the Jagged1-Notch Pathway
Xiangyou Hu et al.
CELL REPORTS (2013)
Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations
Yechun Xu et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2012)
Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: Application to a pyrimidine-2,4-diamine template
Tarek Mohamed et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors
Arun K. Ghosh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy
Britt-Marie Swahn et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
A differentially selective sensor with fluorescence turn-on response to Zn2+ and dual-mode ratiometric response to Al3+ in aqueous media
Debabrata Maity et al.
CHEMICAL COMMUNICATIONS (2012)
New developments on the role of NMDA receptors in Alzheimer's disease
Roberto Malinow
CURRENT OPINION IN NEUROBIOLOGY (2012)
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
Peer-Hendrik Kuhn et al.
EMBO JOURNAL (2012)
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation
Gianpaolo Chiriano et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo
Lujia Zhou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Acyl Guanidine Inhibitors of β-Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis
Samuel W. Gerritz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease
Eugenia Trushina et al.
PLOS ONE (2012)
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin
Johannes Prox et al.
EXPERIMENTAL BRAIN RESEARCH (2012)
National estimates of the prevalence of Alzheimer's disease in the United States
Ron Brookmeyer et al.
ALZHEIMERS & DEMENTIA (2011)
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Reisa A. Sperling et al.
ALZHEIMERS & DEMENTIA (2011)
Amyloid Precursor Protein Processing and Alzheimer's Disease
Richard J. O'Brien et al.
ANNUAL REVIEW OF NEUROSCIENCE, VOL 34 (2011)
Processing of the Synaptic Cell Adhesion Molecule Neurexin-3β by Alzheimer Disease α- and γ-Secretases
Nathalie Bot et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)
Yuan Cheng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Novel insights for the treatment of Alzheimer's disease
Alexander Kurz et al.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2011)
Di-substituted pyridinyl aminohydantoins as potent and highly selective human β-secretase (BACE1) inhibitors
Michael S. Malamas et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Pyrrolidine constrained bipyridyl-dansyl click fluoroionophore as selective Al3+ sensor
Debabrata Maity et al.
CHEMICAL COMMUNICATIONS (2010)
Alzheimer's disease: strategies for disease modification
Martin Citron
NATURE REVIEWS DRUG DISCOVERY (2010)
RNA oxidation in Alzheimer disease and related neurodegenerative disorders
Akihiko Nunomura et al.
ACTA NEUROPATHOLOGICA (2009)
A conformational constraint improves a β-secretase inhibitor but for an unexpected reason
Ivory D. Hills et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Aminoimidazoles as Potent and Selective Human β-Secretase (BACE1) Inhibitors
Michael S. Malamas et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
Juha Lauren et al.
NATURE (2009)
Acylguanidine inhibitors of β-secretase:: Optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket
Lee D. Jennings et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production
Hideaki Shimizu et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Application of fragment-based lead generation to the discovery of novel, cyclic amidine β-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency
Philip D. Edwards et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons
Jenny M. Gunnersen et al.
NEURON (2007)
Thiophene substituted acylguanidines as BACE1 inhibitors
William F. Fobare et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
2-amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (β-site APP cleaving enzyme):: Use of structure based design to convert a micromolar hit into a nanomolar lead
Ellen W. Baxter et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
β-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques:: Implications for Alzheimer's disease pathogenesis
Jie Zhao et al.
JOURNAL OF NEUROSCIENCE (2007)
Construction of a small peptide library related to inhibitor OM99-2 and its structure-activity relationship to β-secretase
Bin Hu et al.
ACTA PHARMACOLOGICA SINICA (2006)
Acylguanidines as small-molecule β-secretase inhibitors
Derek C. Cole et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions
FM Laird et al.
JOURNAL OF NEUROSCIENCE (2005)
γ-cleavage is dependent on ζ-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain
GJ Zhao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Generation and scavenging of reactive oxygen species in chloroplasts: a submolecular approach
A Edreva
AGRICULTURE ECOSYSTEMS & ENVIRONMENT (2005)
Recent developments in guanylating agents
AR Katritzky et al.
ARKIVOC (2005)
The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves α-, β-, γ-, and ε-like cleavages -: Modulation of APLP-1 processing by N-glycosylation
S Eggert et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Cleavage of amyloid-β precursor protein and amyloid-β precursor-like protein by BACE 1
QM Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Take five -: BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation
C Haass
EMBO JOURNAL (2004)
Multiple cognitive deficits during the transition to Alzheimer's disease
L Bäckman et al.
JOURNAL OF INTERNAL MEDICINE (2004)
Apo and inhibitor complex structures of BACE (β-secretase)
S Patel et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Treatment of Alzheimer's disease: current status and new perspectives
E Scarpini et al.
LANCET NEUROLOGY (2003)
Emerging Alzheimer's disease therapies:: inhibition of β-secretase
M Citron
NEUROBIOLOGY OF AGING (2002)
Control of synaptic strength by glial TNFα
EC Beattie et al.
SCIENCE (2002)
A novel ε-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with notch processing
A Weidemann et al.
BIOCHEMISTRY (2002)
Mechanism of inhibition of β-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide
J Marcinkeviciene et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Structure of the protease domain of memapsin 2 (β-secretase) complexed with inhibitor
L Hong et al.
SCIENCE (2000)
BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein
M Farzan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
L Buée et al.
BRAIN RESEARCH REVIEWS (2000)
Inflammation and Alzheimer's disease
H Akiyama et al.
NEUROBIOLOGY OF AGING (2000)
分享论文
