4.7 Review

Capsaicin, its clinical significance in patients with painful diabetic neuropathy

期刊

BIOMEDICINE & PHARMACOTHERAPY
卷 153, 期 -, 页码 -

出版社

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2022.113439

关键词

Diabetes mellitus; Diabetic neuropathy; Capsaicin; Topical capsaicin; Pain relief; Clinical trials

资金

  1. Biomedical Research and Innovation Platform of the South African Medical Research Council (SAMRC)
  2. National Research Foundation [117829]

向作者/读者索取更多资源

Diabetic neuropathy is a serious condition that can lead to various complications and severely impact a patient's quality of life. The use of topical capsaicin cream has shown promising results in reducing pain symptoms and improving walking, working, and sleeping in patients with painful diabetic neuropathy.
Diabetic neuropathy is a risk factor for developing complications such as autonomic cardiovascular disease, osteoarthropathy, foot ulcers, and infections, which may be the direct cause of death. Even worse, patients plagued by this condition display painful neuropathic symptoms that are usually severe and frequently lead to depression, anxiety, and sleep disarrays, eventually leading to a poor quality of life. There is a general interest in evaluating the therapeutic properties of topical capsaicin cream as an effective agent for pain relief in these patients. As such, the current review makes use of major search engines like PubMed and Google Scholar, to bring an updated analysis of clinical studies reporting on the therapeutic effects of capsaicin in patients with painful diabetic neuropathy. In fact, most of the summarized literature indicates that topical capsaicin (0.075 %) cream, when applied to the painful areas for approximately 8 weeks, can reduce pain, which may lead to clinical improvements in walking, working, and sleeping in patients with painful diabetic neuropathy. The current re-view also discusses essential information on capsaicin, including its source, bioavailability profile, as well as treatment doses and duration, to highlight its therapeutic potential.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据