4.7 Article

Radix polygoni multiflori protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting the HDAC4/JNK pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

JNK-dependent phosphorylation and nuclear translocation of EGR-1 promotes cardiomyocyte apoptosis

Jinrun Zhou et al.

Summary: Myocardial apoptosis induced by myocardial ischemia and hyperlipemia are the main causes of high mortality of cardiovascular diseases. This study found that early growth response protein 1 (EGR-1) is involved in both types of apoptosis and identified the mechanism of EGR-1 entering the nucleus.

APOPTOSIS (2022)

Article Chemistry, Multidisciplinary

Paeoniflorin ameliorates ischemic injury in rat brain via inhibiting cytochrome c/caspase3/HDAC4 pathway

Yi-fei Liu et al.

Summary: The study found that Paeoniflorin protects primary rat cortical neurons from ischemic brain injury by maintaining HDAC4 subcellular localization, reducing caspase3 activity, and increasing the expression of protective proteins such as GDNF.

ACTA PHARMACOLOGICA SINICA (2022)

Article Cardiac & Cardiovascular Systems

MicroRNA-200b-3p promotes endothelial cell apoptosis by targeting HDAC4 in atherosclerosis

Fan Zhang et al.

Summary: The study found 250 differentially expressed miRNAs in EAT from CAD patients, mainly related to metabolism, extracellular matrix, and inflammation processes. The expression levels of miR-200 family members, rich in endothelial cells, were significantly increased in EAT from CAD patients. Overexpression of miR-200b-3p targeting HDAC4 inhibition could promote endothelial cell apoptosis under oxidative stress.

BMC CARDIOVASCULAR DISORDERS (2021)

Article Plant Sciences

Exploration of components and mechanisms of Polygoni Multiflori Radix-induced hepatotoxicity using siRNA -mediated CYP3A4 or UGT1A1 knockdown liver cells

Ying-huan Hu et al.

Summary: The study aimed to explore the effect of inhibiting CYP3A4 or UGT1A1 on PMR-ILI, screen relevant hepatotoxic components, and unveil the mechanism. The results showed that EM and GA may be the main hepatotoxic components in PMR, with mechanism related to elevated levels of ROS, mitochondrial membrane potential, Ca2+ concentration, and induction of apoptosis in liver cells.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Distinct metabonomic signatures of Polygoni Multiflori Radix Praeparata against glucolipid metabolic disorders

Ya-Qin Yang et al.

Summary: This study elucidated the effects of Polygoni Multilori Radix Preparata (PMRP) in regulating mitochondria dysfunction and alleviating glucolipid metabolic disorders (GLMD) using mitochondrial metabonomics. The results showed that PMRP could improve liver mitochondrial function by regulating metabolic pathways, indicating its potential as a promising nutrient for alleviating GLMD-associated diseases.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Npas4 impairs fear memory via phosphorylated HDAC5 induced by CGRP administration in mice

Narumi Hashikawa-Hobara et al.

Summary: The study revealed that CGRP impaired traumatic fear memories by increasing Npas4, HDAC5, and PKD levels, with Npas4 playing a crucial role. Inhibition of PKD could attenuate the impairing effect of CGRP on fear memory. These findings suggest a novel function for CGRP in fear memory regulation through epigenetic mechanisms.

SCIENTIFIC REPORTS (2021)

Article Neurosciences

Increased Abundance of Nuclear HDAC4 Impairs Neuronal Development and Long-Term Memory

Patrick Main et al.

Summary: Dysregulation of histone deacetylase HDAC4 is linked to neurodevelopmental and neurodegenerative disorders, with impaired cognitive function being a common feature. Research in Drosophila indicates that alterations in the subcellular distribution of HDAC4 can lead to deficits in mushroom body morphogenesis, eye development, and long-term memory, potentially through mechanisms independent of MEF2 activity. Understanding the role of HDAC4 in neural dysfunction offers new insights into therapeutic strategies for neurological disorders.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Article Multidisciplinary Sciences

The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity

Dinh Thi Nguyen et al.

Summary: ATF6 beta is highly expressed in the hippocampus and regulates the expression of molecular chaperone CRT in the ER, enhancing neuronal survival under ER stress conditions. The deficiency of ATF6 beta leads to reduced Ca2+ stores in the ER and increased ER stress-induced death in hippocampal neurons.

SCIENTIFIC REPORTS (2021)

Article Pharmacology & Pharmacy

Combination of Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma Alleviates Learning and Memory Impairment in Scopolamine-Treated Mice by Regulating Synaptic-Related Proteins

Funan Ning et al.

Summary: The study identified the major components of Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma, and found that their traditional combination has a protective effect on cognitive function by increasing neurotransmitter levels in the hippocampus and activating related proteins.

FRONTIERS IN PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Effects of hippocampal histone acetylation and HDAC inhibition on spatial learning and memory in the Morris water maze in rats

Ruhan Deniz Topuz et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2020)

Review Chemistry, Medicinal

Histone deacetylase (HDAC) inhibitors in cancer: a patent review (2017-present)

Chunlong Zhao et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2020)

Article Endocrinology & Metabolism

A novel hippocampus metabolite signature in diabetes mellitus rat model of diabetic encephalopathy

Guanghui Chen et al.

METABOLIC BRAIN DISEASE (2020)

Article Neurosciences

Diabetic Encephalopathy Affecting Mitochondria and Axonal Transport Proteins

Maryam Eslami Gharaati et al.

BASIC AND CLINICAL NEUROSCIENCE (2020)

Article Cell Biology

Ferrostatin-1 protects HT-22 cells from oxidative toxicity

Jun Chu et al.

NEURAL REGENERATION RESEARCH (2020)

Article Biochemistry & Molecular Biology

Diabetic encephalopathy: beneficial effects of supplementation with fatty acids 3 and nordihydroguaiaretic acid in a spontaneous diabetes rat model

Gustavo Tomas Diaz-Gerevini et al.

LIPIDS IN HEALTH AND DISEASE (2019)

Article Plant Sciences

Trichostatin A Triggers an Embryogenic Transition in Arabidopsis Explants via an Auxin-Related Pathway

Barbara Wojcikowska et al.

FRONTIERS IN PLANT SCIENCE (2018)

Article Multidisciplinary Sciences

m6A facilitates hippocampus-dependent learning and memory through YTHDF1

Hailing Shi et al.

NATURE (2018)

Article Biochemistry & Molecular Biology

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder

Stefania Trazzi et al.

HUMAN MOLECULAR GENETICS (2016)

Review Chemistry, Medicinal

JNK pathway signaling: a novel and smarter therapeutic targets for various biological diseases

Ankit Kumar et al.

FUTURE MEDICINAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

Jiali Li et al.

NATURE MEDICINE (2012)

Article Pharmacology & Pharmacy

Tetrahydroxystilbene glucoside, a plant-derived cognitive enhancer, promotes hippocampal synaptic plasticity

Ting Wang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

Article Chemistry, Analytical

Sensitive and robust UPLC-MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide

Wei Liu et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2011)