4.7 Article

Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin

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Summary: Metformin, an oral antihyperglycemic drug, not only treats type 2 diabetes mellitus but also demonstrates beneficial effects in various kidney diseases by activating AMPK. It protects renal cells from inflammation, apoptosis, and stress, alleviates podocyte loss and fibrosis, and inhibits cyst formation. However, clinical data may not always align with preclinical findings, with some showing minimal or negative effects on T2DM patients with kidney diseases. The issue of metformin-associated lactic acidosis also poses challenges to its application.

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