期刊
BIOMATERIALS
卷 290, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2022.121815
关键词
Light-activatable nanocomplex; Temperate -heat PTT; Cancer immunotherapy; Tumor metastasis; Tumor recurrence
资金
- National Natural Science Foundation of China
- Funds of Sichuan Province for Distinguished Young Scholar
- 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University
- [82172094]
- [2021JDJQ0037]
- [ZYYC08002]
This study reports a multifunctional light-activatable nanocomplex that avoids hyperthermia and achieves temperate-heat photothermal therapy (PTT) to induce extensive apoptosis, enhance anti-tumor immune response, and inhibit tumor metastasis and recurrence. The nanocomplex maintains a specific temperature upon near-infrared irradiation, allowing controlled drug release to disrupt the thermoresistance of tumor cells. Additionally, it promotes tumor perfusion of dendritic cells (DCs) and T lymphocytes, alleviates the immunosuppressive microenvironment, and elicits a strong systemic immune response.
Photothermal therapy (PTT) has been known as an effective weapon against cancer. However, the necrosis induced by hyperthermia post PTT can trigger excessive inflammation response and arouse tumor self-protection resulting in tumor immunosuppression, metastasis and recurrence. To settle this issue, we here reported a multifunctional light-activatable nanocomplex (MILAN) to avoid hyperthermia and achieve temperate-heat PTT for extensive apoptosis, but not necrosis, and further antitumor immune response augmentation to inhibit metastasis and recurrence. Upon NIR irradiation, MILAN would controllably maintain around 43 degrees C, thus evoking the temperature-triggered phase transformation for the controllable drug release. Then, the released gambogic acid broke the thermoresistance of tumor cells, realizing enhanced apoptosis. Thereafter, the generated tumor-associated antigen accompanied with MILAN could facilitate dendritic cells (DCs) maturation for improved antigen presentation. Furthermore, MILAN promoted the tumor perfusion of DCs and T lymphocytes in triple-negative breast cancer (TNBC) models. Simultaneously, the immunosuppressive microenvironment was relieved and a strong systemic immune response was elicited against tumor progress through MILAN. Conse-quently, systemic immunity and persistent immune memory effect were fortified for pronounced cancer metastasis and recurrence inhibition. This work tactfully avoids the side effects of hyperthermia and brought a novel insight into cancer immunotherapy against TNBC.
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