4.8 Article

Large-depth three-photon fluorescence microscopy imaging of cortical microvasculature on nonhuman primates with bright ATE probe In vivo

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Endocrinology & Metabolism

Chronic cerebral hypoperfusion and blood-brain barrier disruption in uninjured brain areas of rhesus monkeys subjected to transient ischemic stroke

Yingqian Zhang et al.

Summary: This study investigated cerebral vascular abnormalities in the chronic phase of ischemic stroke, and found significant cerebral hypoperfusion, blood-brain barrier disruption, and decreased levels of A beta in the cerebrospinal fluid during the rehabilitation stage. These findings contribute to a better understanding of the relationship between cerebrovascular disruptions and long-term neurological deficits.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2022)

Article Immunology

Intravital three-photon microscopy allows visualization over the entire depth of mouse lymph nodes

Kibaek Choe et al.

Summary: Intravital three-photon microscopy allows for the visualization of immune cell behavior in mouse lymph nodes at depths of 600-900 μm. This technique enables measurement of migration ability in different depths and the observation of inflammation effects on T cell motility.

NATURE IMMUNOLOGY (2022)

Article Chemistry, Multidisciplinary

Deep-Brain Three-Photon Imaging Enabled by Aggregation-Induced Emission Luminogens with Near-Infrared-III Excitation

Zhourui Xu et al.

Summary: Understanding the morphology and hemodynamics of cerebral vasculature is crucial for studying brain diseases. This study introduces a series of AIEgens that can be used as effective probes for three-photon microscopy with deep penetration and high resolution. The optimized AIEgens were successfully applied to visualize blood vessels and characterize hemodynamics in deep mouse brain.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Intra- and Intermolecular Synergistic Engineering of Aggregation-Induced Emission Luminogens to Boost Three-Photon Absorption for Through-Skull Brain Imaging

Zheng Zheng et al.

Summary: This study successfully synthesized four bright fluorophores with aggregation-induced emission features, which exhibited high quantum yields. One of the fluorophores (DCBT) showed bright near-infrared emission and large three-photon absorption cross section, which was further enhanced by molecular stacking. These fluorophores were applied in three-photon fluorescence microscopy imaging of mouse brain vasculature with high spatial resolution, and even small capillaries could be identified below the skull.

ACS NANO (2022)

Article Chemistry, Physical

Renal clearable polyfluorophore nanosensors for early diagnosis of cancer and allograft rejection

Jiaguo Huang et al.

Summary: This study develops activatable polyfluorophore nanosensors that can react with disease-associated proteases to produce fluorescent signals for non-invasive disease diagnosis. These nanosensors show promising results in detecting tumors and diagnosing acute liver allograft rejection in rodent models.

NATURE MATERIALS (2022)

Article Neurosciences

Cortical layer-specific differences in stimulus selectivity revealed with high-field fMRI and single-vessel resolution optical imaging of the primary visual cortex

Shinho Cho et al.

Summary: The study reveals that laminar differences in neuronal circuitry are not necessarily reflected in hemodynamic signals. By examining the primary visual cortex in cats, it was found that orientation selectivity in cortical layer 4 was significantly lower compared to layer 2/3 in response to visual stimuli.

NEUROIMAGE (2022)

Article Chemistry, Multidisciplinary

In Vivo Three-Photon Imaging of Lipids using Ultrabright Fluorogens with Aggregation-Induced Emission

Shaowei Wang et al.

Summary: Organic dots with aggregation-induced emission (AIEgen) have been developed for in vivo labeling and imaging of lipid-rich tissues, showing high targeting specificity and stability, as well as strong three-photon fluorescence imaging in deep tissues under NIR-II laser excitation. This study will inspire the development of lipid-targeting fluorophores for in vivo applications.

ADVANCED MATERIALS (2021)

Article Biochemical Research Methods

High-resolution structural and functional deep brain imaging using adaptive optics three-photon microscopy

Lina Streich et al.

Summary: The article introduces a minimally invasive intravital imaging technique based on three-photon excitation, adaptive optics, and electrocardiogram gating for high-resolution imaging of neurons and astrocytes in the mouse brain up to a depth of 1.4 mm.

NATURE METHODS (2021)

Article Biochemical Research Methods

An adaptive optics module for deep tissue multiphoton imaging in vivo

Cristina Rodriguez et al.

Summary: The development of a compact adaptive optics module has enabled correction of tissue-induced aberrations in two-photon and three-photon fluorescence microscopes, allowing high-resolution imaging of synaptic structures in deep regions of the mouse brain and spinal cord, as well as somatosensory-evoked calcium responses. This advancement has facilitated structural and functional imaging deep within living organisms such as mice and zebrafish larvae.

NATURE METHODS (2021)

Article Multidisciplinary Sciences

Multicolor three-photon fluorescence imaging with single-wavelength excitation deep in mouse brain

Yusaku Hontani et al.

Summary: Multiphoton fluorescence microscopy, particularly three-photon microscopy, offers significant advantages for deep-tissue imaging due to long excitation wavelengths and high nonlinear confinement. A new three-photon excitation scheme has been developed to enable multicolor imaging with single-wavelength excitation, resulting in enhanced signal for some red fluorescent molecules. This advancement has the potential to open new opportunities for life science applications of three-photon microscopy.

SCIENCE ADVANCES (2021)

Review Nanoscience & Nanotechnology

Molecular imaging and disease theranostics with renal-clearable optical agents

Penghui Cheng et al.

Summary: Renal-clearable optical agents (RCOAs) are rapidly excreted from the body via the kidneys, making them suitable for targeted kidney imaging and early kidney injury detection, as well as deep tumor penetration and high-contrast tumor imaging.

NATURE REVIEWS MATERIALS (2021)

Article Biochemical Research Methods

Three-photon head-mounted microscope for imaging deep cortical layers in freely moving rats

Alexandr Klioutchnikov et al.

NATURE METHODS (2020)

Article Biochemical Research Methods

Deep three-photon imaging of the brain in intact adult zebrafish

Dawnis M. Chow et al.

NATURE METHODS (2020)

Article Multidisciplinary Sciences

Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates

Zonghai Sheng et al.

RESEARCH (2020)

Article Medicine, Research & Experimental

NIR-II fluorescence microscopic imaging of cortical vasculature in non-human primates

Zhaochong Cai et al.

THERANOSTICS (2020)

Article Biochemical Research Methods

Optical properties of adult Drosophila brains in one-, two-, and three-photon microscopy

Kuo-Jen Hsu et al.

BIOMEDICAL OPTICS EXPRESS (2019)

Article Chemistry, Multidisciplinary

In Vivo Deep-Brain Structural and Hemodynamic Multiphoton Microscopy Enabled by Quantum Dots

Hongji Liu et al.

NANO LETTERS (2019)

Article Multidisciplinary Sciences

Functional imaging of visual cortical layers and subplate in awake mice with optimized three-photon microscopy

Murat Yildirim et al.

NATURE COMMUNICATIONS (2019)

Article Optics

Dual-color deep-tissue three-photon microscopy with a multiband infrared laser

Khmaies Guesmi et al.

LIGHT-SCIENCE & APPLICATIONS (2018)

Article Biochemical Research Methods

Three-photon imaging of mouse brain structure and function through the intact skull

Tianyu Wang et al.

NATURE METHODS (2018)

Article Chemistry, Multidisciplinary

Dose Dependencies and Biocompatibility of Renal Clearable Gold Nanoparticles: From Mice to Non-human Primates

Jing Xu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Article Optics

Wide-field three-photon excitation in biological samples

Christopher J. Rowlands et al.

LIGHT-SCIENCE & APPLICATIONS (2017)

Article Biotechnology & Applied Microbiology

Molecular afterglow imaging with bright, biodegradable polymer nanoparticles

Qingqing Miao et al.

NATURE BIOTECHNOLOGY (2017)

Article Biochemical Research Methods

In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain

Dimitre G. Ouzounov et al.

NATURE METHODS (2017)

Article Neurosciences

Long-Term Two-Photon Imaging in Awake Macaque Monkey

Ming Li et al.

NEURON (2017)

Article Engineering, Biomedical

Bright AIE Nanoparticles with F127 Encapsulation for Deep-Tissue Three-Photon Intravital Brain Angiography

Yalun Wang et al.

ADVANCED HEALTHCARE MATERIALS (2017)

Article Biochemical Research Methods

Two-photon imaging of cerebral hemodynamics and neural activity in awake and anesthetized marmosets

Thom P. Santisakultarm et al.

JOURNAL OF NEUROSCIENCE METHODS (2016)

Article Biochemical Research Methods

Removable cranial windows for long-term imaging in awake mice

Glenn J. Goldey et al.

NATURE PROTOCOLS (2014)

Article Chemistry, Multidisciplinary

Assessing Clinical Prospects of Silicon Quantum Dots: Studies in Mice and Monkeys

Jianwei Liu et al.

ACS NANO (2013)

Article Nanoscience & Nanotechnology

A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots

Ling Ye et al.

NATURE NANOTECHNOLOGY (2012)

Article Developmental Biology

A 3D-investigation shows that angiogenesis in primate cerebral cortex mainly occurs at capillary level

Laurent Risser et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2009)

Article Endocrinology & Metabolism

From homogeneous to fractal normal and tumorous microvascular networks in the brain

Laurent Risser et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2007)

Article Clinical Neurology

Capillary changes in hippocampal CA1 and CA3 areas of the aging rhesus monkey

JIH Keuker et al.

ACTA NEUROPATHOLOGICA (2000)