Hybrid M13 bacteriophage-based vaccine platform for personalized cancer immunotherapy

Article Engineering, Biomedical

Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock

Michael Super et al.

Summary: Injectable biomaterial vaccines designed to magnetically capture pathogen-associated molecular patterns protect mice and pigs against septic shock from lethal bacterial infections.

NATURE BIOMEDICAL ENGINEERING (2022)

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Review Immunology

How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

Payel Roy et al.

Summary: Atherosclerosis involves an inappropriate inflammatory response, with crucial roles played by immune cells. Understanding the regulatory mechanisms of immune cells in atherosclerosis is crucial for developing therapeutic interventions.

NATURE REVIEWS IMMUNOLOGY (2022)

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Review Immunology

Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms

David J. Lynn et al.

Summary: The need for highly effective vaccines that induce robust and long-lasting immunity is increasingly apparent. The composition and function of the gut microbiota are now recognized as crucial factors modulating immune responses to vaccination. Targeted interventions towards the microbiota may hold potential in optimizing vaccine effectiveness.

NATURE REVIEWS IMMUNOLOGY (2022)

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Article Chemistry, Physical

A DNA nanodevice-based vaccine for cancer immunotherapy

Shaoli Liu et al.

Summary: A DNA nanodevice vaccine has been developed to stimulate a tumor-specific cytotoxic T lymphocyte response, leading to inhibition of tumor growth and prevention of metastasis. The vaccine utilizes molecular adjuvants and antigen peptides within a tubular DNA nanostructure to trigger T-cell activation and cancer cytotoxicity, showing promising results in mouse cancer models. The vaccination generates long-term T-cell responses which effectively protect against tumor rechallenge.

NATURE MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Considerations for designing preclinical cancer immune nanomedicine studies

Wen Jiang et al.

Summary: Cancer immune nanomedicine faces complexities and challenges in practice, requiring researchers to consider factors such as tumor response complexity and immunotherapy comprehensively. Researchers need to delve into the internal and external influencing factors of tumors to better design experiments in cancer immune nanomedicine.

NATURE NANOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Development of a Cancer Vaccine Using In Vivo Click-Chemistry-Mediated Active Lymph Node Accumulation for Improved Immunotherapy

Hao Qin et al.

Summary: The development of an active lymph node accumulation system (ALAS) using click chemistry has shown promising results in enhancing the delivery of cancer vaccine components to lymph nodes, leading to improved antitumor immunity.

ADVANCED MATERIALS (2021)

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Review Biotechnology & Applied Microbiology

Emerging concepts in the science of vaccine adjuvants

Bali Pulendran et al.

Summary: Adjuvants are vaccine components that enhance the immune response. Recent advances in understanding the molecular mechanisms and systems vaccinology have revitalized the science and development of novel adjuvants for use in vaccines against COVID-19 and future pandemics.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Chemistry, Multidisciplinary

Biological membrane derived nanomedicines for cancer therapy

Lele Sun et al.

Summary: Nanomedicine systems derived from biological membranes have shown unique advantages in cancer treatment compared to traditional artificial nanomaterials. Two major categories of membrane-derived nanomedicines include synthetic nanoparticles camouflaged with cell membranes for additional functionalities, and engineered cell membrane-derived vesicles or nanovesicles for tumor treatment. Challenges towards future clinical applications of membrane-derived nanomedicines are discussed, along with perspectives on potential solutions to current problems.

SCIENCE CHINA-CHEMISTRY (2021)

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Article Multidisciplinary Sciences

PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy

Julia Koerner et al.

Summary: PLGA-based cancer immunotherapy incorporating antigens and TLR ligands has led to enhanced anti-tumor responses. The study explores the use of a defined dsRNA adjuvant, Riboxxim, and demonstrates its incorporation with PLGA immunotherapy in in vivo tumor models, resulting in enhanced induction of anti-tumor response.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

Keman Cheng et al.

Summary: The study demonstrates a versatile OMV-based vaccine platform that can elicit a specific anti-tumor immune response by specifically presenting tumor antigens on the OMV surface. By employing a Plug-and-Display system, the engineered OMVs can simultaneously display multiple, distinct tumor antigens to promote a synergistic anti-tumor immune response.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Adjuvant oncolytic virotherapy for personalized anti-cancer vaccination

D. G. Roy et al.

Summary: Vaccination with oncolytic viruses co-administered with tumour antigenic peptides is as efficient as antigen-engineered oncolytic viruses, providing a potential alternative for personalized anti-cancer vaccines targeting patient-specific mutations.

NATURE COMMUNICATIONS (2021)

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Review Chemistry, Multidisciplinary

Harnessing Innate Immunity Using Biomaterials for Cancer Immunotherapy

DaeYong Lee et al.

Summary: The discovery of immune checkpoint blockade has revolutionized cancer treatment, but current immunotherapies are only effective for a small subset of patients. Future advancements in cancer immunotherapy will focus on developing novel therapeutic molecules or immunoengineered cells. Biomaterials can efficiently reprogram and recruit immune cells in tumors to activate T cell immunity against advanced cancers.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Coordination Polymers Integrating Metalloimmunology with Immune Modulation to Elicit Robust Cancer Chemoimmunotherapy

Longlong Tian et al.

Summary: The study successfully achieved a smart design of NCPs as carrier-free drug delivery system for highly effective chemoimmunotherapy in cancer treatment, inducing immunogenic cell death and inhibiting tumor growth.

CCS CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

PhotothermalPhage: A Virus-Based Photothermal Therapeutic Agent

Arezoo Shahrivarkevishahi et al.

Summary: A new generation immunophotothermal agent is developed by utilizing a chemically modified VLP called bacteriophage Q beta to adjuvant photothermal ablation. This system, named PhotothermalPhage, combines the benefits of near-infrared absorbing croconium dyes with the structure of VLPs to generate more heat and act as an immunoadjuvant, leading to effective tumor suppression and increased survival time.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Cell Biology

Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines

Long Chen et al.

Summary: Utilizing Escherichia coli cytoplasmic membranes as adjuvants, a vaccine based on hybrid membrane nanoparticles containing tumor cell membranes induced sufficient antitumor reactivity without notable adverse effects, showing efficacy in various tumor mouse models and providing long-term protection against tumor rechallenge.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Biochemical Research Methods

Development of a Novel Cytokine Vehicle Using Filamentous Phage Display for Colorectal Cancer Treatment

Han Ying Wang et al.

Summary: A novel therapeutic platform utilizing filamentous phage to display an antitumor cytokine was developed and demonstrated significant antitumor activities in a murine colorectal cancer model. The combined therapy of the cytokine phage and radiation greatly improved therapeutic potency, leading to 100% survival rate and 25% complete remission rate, indicating the potential for multifunctional nanoparticles for cancer therapy.

ACS SYNTHETIC BIOLOGY (2021)

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Review Oncology

Therapeutic cancer vaccines

Mansi Saxena et al.

Summary: Therapeutic cancer vaccines aim to induce tumor regression, eradicate minimal residual disease, establish lasting anti-tumor memory, and avoid non-specific or adverse reactions. However, challenges arise due to tumor-induced immunosuppression and immunoresistance, hindering the achievement of these goals.

NATURE REVIEWS CANCER (2021)

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Article Oncology

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

John D. Martin et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Cell Biology

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Candice R. Gurbatri et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Chemistry, Multidisciplinary

Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine

Lixia Wei et al.

ACS CENTRAL SCIENCE (2020)

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Article Multidisciplinary Sciences

A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy

Di-Wei Zheng et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Bioinorganic hybrid bacteriophage for modulation of intestinal microbiota to remodel tumor-immune microenvironment against colorectal cancer

Xue Dong et al.

SCIENCE ADVANCES (2020)

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Article Multidisciplinary Sciences

Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination

Xiaobo Xi et al.

SCIENCE ADVANCES (2020)

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Review Oncology

Moving towards personalized treatments of immune-related adverse events

Khashayar Esfahani et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Microbiology

Recombinant Filamentous Bacteriophages Encapsulated in Biodegradable Polymeric Microparticles for Stimulation of Innate and Adaptive Immune Responses

Rezvan Jamaledin et al.

MICROORGANISMS (2020)

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Article Biotechnology & Applied Microbiology

Antitumour dendritic cell vaccination in a priming and boosting approach

Alexandre Harari et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Article Multidisciplinary Sciences

A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity

Xia Li et al.

NATURE COMMUNICATIONS (2020)

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Article Nanoscience & Nanotechnology

Proton-driven transformable nanovaccine for cancer immunotherapy

Ningqiang Gong et al.

NATURE NANOTECHNOLOGY (2020)

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Article Multidisciplinary Sciences

An implantable blood clot-based immune niche for enhanced cancer vaccination

Qin Fan et al.

SCIENCE ADVANCES (2020)

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Review Chemistry, Multidisciplinary

Biosynthesis of inorganic nanomaterials using microbial cells and bacteriophages

Yoojin Choi et al.

NATURE REVIEWS CHEMISTRY (2020)

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Article Multidisciplinary Sciences

Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors

Hua Wang et al.

NATURE COMMUNICATIONS (2020)

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Article Nanoscience & Nanotechnology

A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy

Jun Xu et al.

NATURE NANOTECHNOLOGY (2020)

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Review Immunology

A guide to cancer immunotherapy: from T cell basic science to clinical practice

Alex D. Waldman et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Pharmacology & Pharmacy

Bacteriophage T4 nanoparticles for vaccine delivery against infectious diseases

Pan Tao et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Multidisciplinary Sciences

Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells

Wen-Long Liu et al.

NATURE COMMUNICATIONS (2019)

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Review Pharmacology & Pharmacy

Bacteriophage interactions with mammalian tissue: Therapeutic applications

Haein Huh et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Review Pharmacology & Pharmacy

Phage-based vaccines

Qing Bao et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Nanoscience & Nanotechnology

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

Qian Chen et al.

NATURE NANOTECHNOLOGY (2019)

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Review Chemistry, Physical

Designing natural and synthetic immune tissues

Emily A. Gosselin et al.

NATURE MATERIALS (2018)

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Article Chemistry, Physical

A facile approach to enhance antigen response for personalized cancer vaccination

Aileen Weiwei Li et al.

NATURE MATERIALS (2018)

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Review Immunology

Towards personalized, tumour-specific, therapeutic vaccines for cancer

Zhuting Hu et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Article Chemistry, Physical

Designer vaccine nanodiscs for personalized cancer immunotherapy

Rui Kuai et al.

NATURE MATERIALS (2017)

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Review Chemistry, Multidisciplinary

Phage-Enabled Nanomedicine: From Probes to Therapeutics in Precision Medicine

Kegan S. Sunderland et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Review Pharmacology & Pharmacy

Bacteriophages and phage-inspired nanocarriers for targeted delivery of therapeutic cargos

Mahdi Karimi et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Review Immunology

Type I interferons in anticancer immunity

Laurence Zitvogel et al.

NATURE REVIEWS IMMUNOLOGY (2015)

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Review Chemistry, Physical

Engineering synthetic vaccines using cues from natural immunity

Darrell J. Irvine et al.

NATURE MATERIALS (2013)

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Review Immunology

Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination

Christophe J. Desmet et al.

NATURE REVIEWS IMMUNOLOGY (2012)

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Article Chemistry, Physical

Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

James J. Moon et al.

NATURE MATERIALS (2011)

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Article Nanoscience & Nanotechnology

Three-dimensional tissue culture based on magnetic cell levitation

Glauco R. Souza et al.

NATURE NANOTECHNOLOGY (2010)

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Hybrid M13 bacteriophage-based vaccine platform for personalized cancer immunotherapy

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