4.3 Article

Association of vitamin B12/ferritin deficiency in cancer patients with methylomic changes at promotors of TET methylcytosine dioxygenases

期刊

BIOMARKERS IN MEDICINE
卷 16, 期 13, 页码 959-970

出版社

FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2022-0158

关键词

cancer; epigenetic changes; ferritin; methylcytosine dioxygenases; vitamin B12

向作者/读者索取更多资源

The study found that cancer patients with low levels of vitamin B12 and ferritin showed changes in the expression of specific genes and progression of DNA methylation.
Aim: To investigate potential DNA methylation in methylcytosine dioxygenases and correlation of TET genes with vitamin B12/ferritin levels in cancer patients. Materials & methods: 200 blood samples were obtained from both cancer patients and healthy individuals. Results: The expression of DNMT1, DNMT3a and DNMT3b was increased in patients with low vitamin B12 and ferritin levels, while the expression of MTR, TET1 and TET3 significantly decreased. DNA methylation analysis in patients with deficient vitamin B12/ferritin levels showed methylomic changes within the location 318/CG and 385/CG in the promoter region of TET1 and TET3, respectively. Conclusion: Vitamin B12/ferritin deficiency contributes to DNA methylation progress in cancer patients.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据