期刊
BIOMACROMOLECULES
卷 23, 期 10, 页码 4401-4411出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.2c00878
关键词
-
资金
- American Diabetes Association Pathway Award [1- 19 -ACE -31]
- Helmsley Charitable Trust [2019PG- T1D016]
- Juvenile Diabetes Research Foundation [5-CDA-2020-947-A-N]
This study demonstrates a method for fabricating polymeric microneedle patches using dynamic-covalent crosslinking. By utilizing the dual role of phenylboronic acid (PBA)-diol bonds, both network crosslinking and glucose sensing capabilities are achieved. The results show that this microneedle patch can release insulin rapidly on the skin and effectively control blood glucose levels in diabetic patients. This approach circumvents the toxicity concerns of in situ polymerization and offers a convenient device form factor for therapeutic insulin delivery.
The ongoing rise in diabetes incidence necessitates improved therapeutic strategies to enable precise blood glucose control with convenient device form factors. Microneedle patches are one such device platform capable of achieving therapeutic delivery through the skin. In recent years, polymeric microneedle arrays have been reported using methods of in situ polymerization and covalent crosslinking in microneedle molds. In spite of promising results, in situ polymerization carries a risk of exposure to toxic unreacted precursors remaining in the device. Here, a polymeric microneedle patch is demonstrated that uses dynamic-covalent phenylboronic acid (PBA)-diol bonds in a dual role affording both network crosslinking and glucose sensing. By this approach, a pre-synthesized and purified polymer bearing pendant PBA motifs is combined with a multivalent diol crosslinker to prepare dynamic-covalent hydrogel networks. The ability of these dynamic hydrogels to shear-thin and self-heal enables their loading to a microneedle mold by centrifugation. Subsequent drying then yields a patch of uniformly shaped microneedles with the requisite mechanical properties to penetrate skin. Insulin release from these materials is accelerated in the presence of glucose. Moreover, short-term blood glucose control in a diabetic rat model following application of the device to the skin confirms insulin activity and bioavailability. Accordingly, dynamic-covalent crosslinking facilitates a route for fabricating microneedle arrays circumventing the toxicity concerns of in situ polymerization, offering a convenient device form factor for therapeutic insulin delivery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据