期刊
BIOESSAYS
卷 44, 期 12, 页码 -出版社
WILEY
DOI: 10.1002/bies.202200128
关键词
asymmetric division; CTPS; cytoophidia; differentiation; IMPDH; plasticity; ribonucleotides
资金
- Cancerfonden grant [19 0096]
- Barncancerfonden grant [PR2019-0089]
Enzymes involved in nucleotide synthesis can form large filament structures called rods and rings, which may be asymmetrically inherited during mammalian cell division and influence cell fate. This asymmetric inheritance, coupled with the dynamic nature of these structures, enables plasticity in a cell population.
Two enzymes involved in the synthesis of pyrimidine and purine nucleotides, CTP synthase (CTPS) and IMP dehydrogenase (IMPDH), can assemble into a single or very few large filaments called rods and rings (RR) or cytoophidia. Most recently, asymmetric cytoplasmic distribution of organelles during cell division has been described as a decisive event in hematopoietic stem cell fate. We propose that cytoophidia, which could be considered as membrane-less organelles, may also be distributed asymmetrically during mammalian cell division as previously described for Schizosaccharomyces pombe. Furthermore, because each type of nucleotide intervenes in distinct processes (e.g., membrane synthesis, glycosylation, and G protein-signaling), alterations in the rate of synthesis of specific nucleotide types could influence cell differentiation in multiple ways. Therefore, we hypothesize that whether a daughter cell inherits or not CTPS or IMPDH filaments determines its fate and that this asymmetric inheritance, together with the dynamic nature of these structures enables plasticity in a cell population.
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