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Design, synthesis and biological evaluation of new Axl kinase inhibitors containing 1,3,4-oxadiazole acetamide moiety as novel linker
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR-Mutated Non-Small Cell Lung Cancer
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CLINICAL CANCER RESEARCH (2020)
Gas6/Axl Signaling Pathway in the Tumor Immune Microenvironment
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
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Axl signaling is an important mediator of tumor angiogenesis
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Oncotarget (2019)
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HAEMATOLOGICA (2019)
AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications
Chenjing Zhu et al.
MOLECULAR CANCER (2019)
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CA-A CANCER JOURNAL FOR CLINICIANS (2019)
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Enapotamab vedotin, an AXL-specific antibody-drug conjugate, shows preclinical antitumor activity in non-small cell lung cancer
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JCI INSIGHT (2019)
Targeting AXL kinase with TP-0903 successfully reverses the mesenchymal phenotype and extends survival in preclinical models of advanced ovarian cancer
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CANCER RESEARCH (2019)
Discovery of N-[4-(Quinolin-4-yloxy)phenyl]benzenesulfonamides as Novel AXL Kinase Inhibitors
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JOURNAL OF MEDICINAL CHEMISTRY (2018)
Axl inhibitors as novel cancer therapeutic agents
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MOLECULAR CANCER (2018)
Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)
Anexelekto /MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms
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HAEMATOLOGICA (2017)
The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase
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JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
AXL-GAS6 expression can predict for adverse prognosis in non-small cell lung cancer with brain metastases
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JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2017)
Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands
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TRENDS IN BIOCHEMICAL SCIENCES (2017)
Key Roles of AXL and MER Receptor Tyrosine Kinases in Resistance to Multiple Anticancer Therapies
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Macrophages promote the progression of premalignant mammary lesions to invasive cancer
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ONCOTARGET (2017)
Anexelekto /MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms
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HAEMATOLOGICA (2017)
Potent preclinical antitumor activity of MGCD265, an oral Met/VEGFR kinase inhibitor in phase II clinical development, in combination with taxanes or erlotinib.
J. M. Besterman et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
A phase Ib/II study of XL184 (BMS 907351) with and without erlotinib (E) in patients (pts) with non-small cell lung cancer (NSCLC).
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JOURNAL OF CLINICAL ONCOLOGY (2017)
AXL-Driven EMT State as a Targetable Conduit in Cancer
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CANCER RESEARCH (2017)
Discovering novel 7-azaindole-based series as potent AXL kinase inhibitors
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective
Samuel H. Myers et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Preclinical combination of TP-0903, an AXL inhibitor and B-PAC-1, a procaspase-activating compound with ibrutinib in chronic lymphocytic leukemia
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LEUKEMIA & LYMPHOMA (2016)
Role of the Receptor Tyrosine Kinase Axl and its Targeting in Cancer Cells
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CURRENT MEDICINAL CHEMISTRY (2016)
4-Oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as New Axl Kinase Inhibitors
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JOURNAL OF MEDICINAL CHEMISTRY (2016)
Axl Receptor Axis: A New Therapeutic Target in Lung Cancer
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JOURNAL OF THORACIC ONCOLOGY (2016)
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BLOOD (2016)
Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors
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CLINICAL CANCER RESEARCH (2015)
Enzymes: principles and biotechnological applications
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The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung
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MUCOSAL IMMUNOLOGY (2015)
Axl inhibition: a potential road to a novel acute myeloid leukemia therapy?
Melanie Janning et al.
EXPERT REVIEW OF HEMATOLOGY (2015)
Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells
Mikaella Vouri et al.
ONCOTARGET (2015)
Role of Flippases, Scramblases and Transfer Proteins in Phosphatidylserine Subcellular Distribution
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TRAFFIC (2015)
Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers
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MET and AXL Inhibitor NPS-1034 Exerts Efficacy against Lung Cancer Cells Resistant to EGFR Kinase Inhibitors Because of MET or AXL Activation
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AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs
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AXL Mediates Resistance to Cetuximab Therapy
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CANCER RESEARCH (2014)
Gas6/Axl pathway promotes tumor invasion through the transcriptional activation of Slug in hepatocellular carcinoma
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CARCINOGENESIS (2014)
NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants
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MOLECULES (2014)
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
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NATURE (2014)
The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma
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ONCOGENE (2014)
Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancer
Y. Wang et al.
CELL DEATH & DISEASE (2014)
The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer
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NATURE REVIEWS CANCER (2014)
TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase
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CANCER RESEARCH (2013)
Sequence Determinants of a Specific Inactive Protein Kinase Conformation
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An Epithelial-Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance
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CLINICAL CANCER RESEARCH (2013)
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Axl Mediates Acquired Resistance of Head and Neck Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Erlotinib
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MOLECULAR CANCER THERAPEUTICS (2013)
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MOLECULAR CANCER THERAPEUTICS (2013)
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The Receptor AXL Diversifies EGFR Signaling and Limits the Response to EGFR-Targeted Inhibitors in Triple-Negative Breast Cancer Cells
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IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations
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SCIENTIFIC REPORTS (2013)
Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation
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CLINICAL & EXPERIMENTAL METASTASIS (2012)
Axl is essential for VEGF-A-dependent activation of PI3K/Akt
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EMBO JOURNAL (2012)
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EUROPEAN JOURNAL OF CANCER (2012)
Hypoxia Stabilizes GAS6/Axl Signaling in Metastatic Prostate Cancer
Anjali Mishra et al.
MOLECULAR CANCER RESEARCH (2012)
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
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NATURE GENETICS (2012)
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CANCER RESEARCH (2011)
Activity of XL184 (Cabozantinib), an Oral Tyrosine Kinase Inhibitor, in Patients With Medullary Thyroid Cancer
Razelle Kurzrock et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
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MOLECULAR CANCER THERAPEUTICS (2011)
Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer
G. Mudduluru et al.
ONCOGENE (2011)
Design, Synthesis, and Biological Evaluation of a Series of Novel AXL Kinase Inhibitors
Alexis Mollard et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
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Gautam K. Malhotra et al.
CANCER BIOLOGY & THERAPY (2010)
R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
Sacha J. Holland et al.
CANCER RESEARCH (2010)
A Phase I Study of Foretinib, a Multi-Targeted Inhibitor of c-Met and Vascular Endothelial Growth Factor Receptor 2
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CLINICAL CANCER RESEARCH (2010)
BMS-777607, a Small-Molecule Met Kinase Inhibitor, Suppresses Hepatocyte Growth Factor-Stimulated Prostate Cancer Metastatic Phenotype In vitro
Yao Dai et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Inhibition of Mer and Axl Receptor Tyrosine Kinases in Astrocytoma Cells Leads to Increased Apoptosis and Improved Chemosensitivity
Amy K. Keating et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL
Li Liu et al.
CANCER RESEARCH (2009)
Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily
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JOURNAL OF MEDICINAL CHEMISTRY (2009)
Antiangiogenic drugs and tyrosine kinases
Jozsef Timar et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2008)
Receptor tyrosine kinase inhibitors in thyroid cancer
Maria Domenica Castellone et al.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2008)
The human receptor tyrosine kinase Axl gene-promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation
Giridhar Mudduluru et al.
BIOSCIENCE REPORTS (2008)
Drug development of MET inhibitors: targeting oncogene addiction and expedience
Paolo M. Comoglio et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Immunobiology of the TAM receptors
Greg Lemke et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
Klarisa Rikova et al.
CELL (2007)
TAM receptors are pleiotropic inhibitors of the innate immune response
Carla V. Rothlin et al.
CELL (2007)
A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors
D. Mahadevan et al.
ONCOGENE (2007)
Identification of novel amplification gene targets in mouse and human breast cancer at a syntenic cluster mapping to mouse ch8A1 and human ch13q34
Martin C. Abba et al.
CANCER RESEARCH (2007)
Rational design of inhibitors that bind to inactive kinase conformations
Y Liu et al.
NATURE CHEMICAL BIOLOGY (2006)
Phosphoproteomic analysis of Her2/neu signaling and inhibition
Ron Bose et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival
P Vajkoczy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Multiple roles for the receptor tyrosine kinase Axl in tumor formation
SJ Holland et al.
CANCER RESEARCH (2005)
Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor
PP Sainaghi et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Ligand recognition and homophilic interactions in Tyro3 -: Structural insights into the Axl/Tyro3 receptor tyrosine kinase family
C Heiring et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts
J Stenhoff et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Met, metastasis, motility and more
C Birchmeier et al.
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Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells
HA Anderson et al.
NATURE IMMUNOLOGY (2003)
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G Manning et al.
SCIENCE (2002)
Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6 -: Receptor tyrosine kinase activation by laminin G-like domains
T Sasaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Estrogen dependent expression of the receptor tyrosine kinase axl in normal and malignant human breast
G Berclaz et al.
ANNALS OF ONCOLOGY (2001)