期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1877, 期 6, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbcan.2022.188826
关键词
Cellular senescence; Microbiota; Pancreatic cancer; Tumor microenvironment; Targeted therapy
资金
- Lanzhou Sci- ence and Technology Development Guiding Plan Project
- National Natural Science Foundation of China
- [ldyyn2020-76]
- [2022-ZD-99]
- [82260555]
Cellular senescence plays a dual role in tissue development and tumor suppression, but can also contribute to age-related diseases. The microbiota is intricately linked to cellular senescence and may play a significant role in tumorigenesis and progression.
Cellular senescence is a state of growth arrest where nonproliferative cells accumulate over time in the aging microenvironment under multiple external factors. Senescent cells exert a double-edged sword effect in an autocrine or paracrine manner: physiologically, they contribute to tissue development, prevent the multiplication of damaged cells and contribute to tissue repair and tumor suppression while favoring the onset of agerelated diseases, including tumors. The microbiota in human tissues is intricately linked to cellular senescence and is reportedly present in the tissues of various tumors (including pancreatic tumors), closely associated with tumorigenesis and progression. The microbiota can induce cells to undergo senescence, and their long-term effects can assist senescent cells in transforming and successfully escaping senescence, contributing to tumorigenesis and progression. Here, we focus on the correlation between the microbiota, cellular senescence, and pancreatic cancer to provide novel ideas for the study and therapy of pancreatic cancer.
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