4.5 Article

Single-cell RNA sequencing analysis of T helper cell differentiation and heterogeneity

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

TRIB3 reduces CD8+ T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer

Shuang Shang et al.

Summary: TRIB3 inhibits CD8(+) T cell infiltration in colorectal cancer by inhibiting STAT1 activation and reducing tumor-infiltrating T cells. Acetyltransferase P300 acetylates TRIB3 and prevents its ubiquitination and degradation. Genetic ablation of TRIB3 or pharmacological acceleration of TRIB3 degradation with a P300 inhibitor increases T cell recruitment and sensitizes colorectal cancers to immune checkpoint blockade therapy.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Article Immunology

Recirculating IL-1R2+ Tregs fine-tune intrathymic Treg development under inflammatory conditions

Eirini Nikolouli et al.

Summary: A specific subset of Foxp3(+) Tregs expressing IL-1R2 has been identified in the thymus, showing characteristics of recirculating cells with an activated phenotype. These Tregs have a thymic origin and play a regulatory role in modulating IL-1 signaling in the thymus.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Biochemical Research Methods

Nebulosa recovers single-cell gene expression signals by kernel density estimation

Jose Alquicira-Hernandez et al.

Summary: Nebulosa is an R package that utilizes weighted kernel density estimation to recover lost signals caused by data sparsity in single-cell experiments, improving the accurate assessment of gene expression.

BIOINFORMATICS (2021)

Article Multidisciplinary Sciences

Mitochondrial gene expression in single cells shape pancreatic beta cells' sub-populations and explain variation in insulin pathway

H. Medini et al.

Summary: Mitochondrial gene expression is crucial for cell metabolism, showing divergence in beta cells of different origins. Specific metabolic and mitochondrial signatures distinguish various sub-populations of beta cells in human and mouse models.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

Integrated analysis of multimodal single-cell data

Yuhan Hao et al.

Summary: The study introduces a weighted-nearest neighbor analysis framework to learn the relative utility of each data type in each cell, enabling integrative analysis of multiple modalities. Applied to a CITE-seq dataset, the method constructs a multimodal reference atlas of the circulating immune system and successfully identifies and validates previously unreported lymphoid subpopulations.
Article Biochemistry & Molecular Biology

The GATOR2?mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation

Allison Ho Kowalsky et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Overexpression of PSAT1 promotes metastasis of lung adenocarcinoma by suppressing the IRF1-IFNγ axis

Yung-Chieh Chan et al.

ONCOGENE (2020)

Article Multidisciplinary Sciences

Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines

Eddie Cano-Gamez et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients

Nicolas Gonzalo Nunez et al.

NATURE COMMUNICATIONS (2020)

Article Immunology

Chemokine Signatures of Pathogen-Specific T Cells I: Effector T Cells

Jens Eberlein et al.

JOURNAL OF IMMUNOLOGY (2020)

Article Biotechnology & Applied Microbiology

A benchmark of batch-effect correction methods for single-cell RNA sequencing data

Hoa Thi Nhu Tran et al.

GENOME BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Benchmark and integration of resources for the estimation of human transcription factor activities

Luz Garcia-Alonso et al.

GENOME RESEARCH (2019)

Review Biochemistry & Molecular Biology

Current best practices in single-cell RNA-seq analysis: a tutorial

Malte D. Luecken et al.

MOLECULAR SYSTEMS BIOLOGY (2019)

Article Biotechnology & Applied Microbiology

Role and plasticity of Th1 and Th17 responses in immunity to Staphylococcus aureus

Alessandra Ferraro et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2019)

Article Biochemical Research Methods

Supervised classification enables rapid annotation of cell atlases

Hannah A. Pliner et al.

NATURE METHODS (2019)

Review Immunology

The Metabolic Requirements of Th2 Cell Differentiation

Julian M. Stark et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

Peter A. Szabo et al.

NATURE COMMUNICATIONS (2019)

Article Rheumatology

Rheumatoid arthritis-associated DNA methylation sites in peripheral blood mononuclear cells

Hong Zhu et al.

ANNALS OF THE RHEUMATIC DISEASES (2019)

Article Biotechnology & Applied Microbiology

Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression

Christoph Hafemeister et al.

GENOME BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Database resources of the National Center for Biotechnology Information

Richa Agarwala et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Cell Biology

T Helper Cell Differentiation, Heterogeneity, and Plasticity

Jinfang Zhu

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

Editorial Material Immunology

TRIMming TGF-β signals in Th17 cells

Aaron S. Rapaport et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Article Biotechnology & Applied Microbiology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler et al.

NATURE BIOTECHNOLOGY (2018)

Article Multidisciplinary Sciences

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression

Silvia Marquez-Jurado et al.

NATURE COMMUNICATIONS (2018)

Review Medicine, Research & Experimental

An Introduction to the Analysis of Single-Cell RNA-Sequencing Data

Aisha A. AlJanahi et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2018)

Review Biochemistry & Molecular Biology

Single-cell RNA sequencing technologies and bioinformatics pipelines

Byungjin Hwang et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

Article Biochemistry & Molecular Biology

Interferon-inducible LY6E Protein Promotes HIV-1 Infection

Jingyou Yu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Immunology

mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation

Olesya Chornoguz et al.

JOURNAL OF IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders

Patrizia Fasching et al.

MOLECULES (2017)

Article Multidisciplinary Sciences

Single-cell RNA-sequencing uncovers transcriptional states and fate decisions in haematopoiesis

Emmanouil I. Athanasiadis et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Massively parallel digital transcriptional profiling of single cells

Grace X. Y. Zheng et al.

NATURE COMMUNICATIONS (2017)

Article Immunology

Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus

Ursula Ellinghaus et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2017)

Article Cell Biology

Serine Is an Essential Metabolite for Effector T Cell Expansion

Eric H. Ma et al.

CELL METABOLISM (2017)

Article Genetics & Heredity

Galectin-3 suppresses mucosal inflammation and reduces disease severity in experimental colitis

Hwei-Fang Tsai et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2016)

Letter Biotechnology & Applied Microbiology

The contribution of cell cycle to heterogeneity in single-cell RNA-seq data

Andrew McDavid et al.

NATURE BIOTECHNOLOGY (2016)

Article Multidisciplinary Sciences

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Itay Tirosh et al.

SCIENCE (2016)

Article Biotechnology & Applied Microbiology

Classification of low quality cells from single-cell RNA-seq data

Tomislav Ilicic et al.

GENOME BIOLOGY (2016)

Article Biotechnology & Applied Microbiology

Patterns of ribosomal protein expression specify normal and malignant human cells

Joao C. Guimaraes et al.

GENOME BIOLOGY (2016)

Article Rheumatology

Helios Enhances Treg Cell Function in Cooperation With FoxP3

Hiroaki Takatori et al.

ARTHRITIS & RHEUMATOLOGY (2015)

Review Allergy

Th17 and Non-Classic Th1 Cells in Chronic Inflammatory Disorders: Two Sides of the Same Coin

Lorenzo Cosmi et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2014)

Article Biotechnology & Applied Microbiology

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

Cole Trapnell et al.

NATURE BIOTECHNOLOGY (2014)

Article Biochemical Research Methods

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

Edward Y. Chen et al.

BMC BIOINFORMATICS (2013)

Review Immunology

TH2, allergy and group 2 innate lymphoid cells

Paula Licona-Limon et al.

NATURE IMMUNOLOGY (2013)

Review Immunology

The plasticity of human Treg and Th17 cells and its role in autoimmunity

Markus Kleinewietfeld et al.

SEMINARS IN IMMUNOLOGY (2013)

Article Biochemistry & Molecular Biology

Regulation of the cell cycle via mitochondrial gene expression and energy metabolism in HeLa cells

Wei Xiong et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2012)

Review Immunology

CD4(+)T Cells: Differentiation and Functions

Rishi Vishal Luckheeram et al.

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2012)

Article Biochemistry & Molecular Biology

The Human Mitochondrial Transcriptome

Tim R. Mercer et al.

Review Genetics & Heredity

LIF in the regulation of T-cell fate and as a potential therapeutic

S. M. Metcalfe

GENES AND IMMUNITY (2011)

Article Cell Biology

GARP: a key receptor controlling FOXP3 in human regulatory T cells

M. Probst-Kepper et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)

Review Immunology

The dynamics of dendritic cell-T cell interactions in priming and tolerance

Stephanie Hugues et al.

CURRENT OPINION IN IMMUNOLOGY (2006)

Article Medicine, Research & Experimental

UBD, a downstream element of FOXP3, allows the identification of LGALS3, a new marker of human regulatory T cells

Frank Ocklenburg et al.

LABORATORY INVESTIGATION (2006)

Article Multidisciplinary Sciences

Interleukin 2 plays a central role in Th2 differentiation

J Cote-Sierra et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

A mitochondrial specific stress response in mammalian cells

Q Zhao et al.

EMBO JOURNAL (2002)