期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1863, 期 8, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbabio.2022.148911
关键词
Oxygen sensor; Hypoxia; Mitochondria; PASMC; Carotid body; Cox4i2
资金
- DFG (German Research Foundation) [268555672 - SFB 1213, A06]
Acclimation to acute hypoxia is mediated by specialized cells in the carotid body and pulmonary vasculature, and recent studies have revealed a common mitochondrial oxygen sensing mechanism in both organs.
Acclimation to acute hypoxia through cardiorespiratory responses is mediated by specialized cells in the carotid body and pulmonary vasculature to optimize systemic arterial oxygenation and thus oxygen supply to the tissues. Acute oxygen sensing by these cells triggers hyperventilation and hypoxic pulmonary vasoconstriction which limits pulmonary blood flow through areas of low alveolar oxygen content. Oxygen sensing of acute hypoxia by specialized cells thus is a fundamental pre-requisite for aerobic life and maintains systemic oxygen supply. However, the primary oxygen sensing mechanism and the question of a common mechanism in different specialized oxygen sensing cells remains unresolved. Recent studies unraveled basic oxygen sensing mechanisms involving the mitochondrial cytochrome c oxidase subunit 4 isoform 2 that is essential for the hypoxia-induced release of mitochondrial reactive oxygen species and subsequent acute hypoxic responses in both, the carotid body and pulmonary vasculature. This review compares basic mitochondrial oxygen sensing mechanisms in the pulmonary vasculature and the carotid body.
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