4.4 Article

NMR Structures of Calmodulin Bound to Two Separate Regulatory Sites in the Retinal Cyclic Nucleotide-Gated Channel

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biophysics

Chemical shift assignments of calmodulin bound to the beta-subunit of a retinal cyclic nucleotide-gated channel (CNGB1)

Aritra Bej et al.

Summary: Rod CNG channels are composed of CNGA1 and CNGB1 protein subunits, where CaM binds to the regulatory domain of CNGB1 and reduces the open probability of CNGA1/CNGB1 channels. The CaM binding site on bovine CNGB1 tightly interacts with Ca2+-bound CaM, leading to Ca2+-induced inactivation of CNGA1/CNGB1 channels in retinal rods.

BIOMOLECULAR NMR ASSIGNMENTS (2022)

Article Biochemistry & Molecular Biology

Structural basis of the partially open central gate in the human CNGA1/CNGB1 channel explained by additional density for calmodulin in cryo-EM map

Diane C. A. Barret et al.

Summary: The recently reported structure of the human CNGA1/CNGB1 CNG channel in the open state shows that the central hydrophobic gate is not completely opened upon cGMP binding. The presence of calmodulin (CaM) in the channel structure suggests its involvement in the partial opening of the gate. This finding helps to understand the different gating mechanisms of CNGA homomeric channels and CNGA1/CNGB1 channels.

JOURNAL OF STRUCTURAL BIOLOGY (2022)

Article Neurosciences

Structural mechanisms of gating and selectivity of human rod CNGA1 channel

Jing Xue et al.

Summary: This study reveals the structural mechanism of ligand gating in the human rod CNGA1 channel, including channel conformation and ion binding sites, providing insights into Ca2+ blockage and permeation in CNG channels.

NEURON (2021)

Review Biochemistry & Molecular Biology

L-Type Ca2+ Channel Regulation by Calmodulin and CaBP1

James B. Ames

Summary: CaM and CaBP1 interact with CaV through binding to the IQ motif to oppositely control Ca2+-dependent channel activity, with CaM promoting CDI and CaBP1 preventing CDI and promoting CDF.

BIOMOLECULES (2021)

Article Biochemistry & Molecular Biology

Calmodulin complexes with brain and muscle creatine kinase peptides

Janina Sprenger et al.

Summary: The study identified a rare 1:2 CaM:peptide binding mode in the CaM-CK complex, demonstrating that each CaM domain can independently bind CK peptide in a Ca2+-dependent manner. While the overall binding mode is similar between muscle or brain-type CK peptides, the opposite binding orientation of the N-terminal domain peptides may lead to distinct binding modes and regulation of full-length CK isoforms.

CURRENT RESEARCH IN STRUCTURAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Retinal degeneration 3 (RD3) protein, a retinal guanylyl cyclase regulator, forms a monomeric and elongated four-helix bundle

Igor V. Peshenko et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Structure of Guanylyl Cyclase Activator Protein 1 (GCAP1) Mutant V77E in a Ca2+-free/Mg2+-bound Activator State

Sunghyuk Lim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

G. C. P. van Zundert et al.

JOURNAL OF MOLECULAR BIOLOGY (2016)

Article Biochemical Research Methods

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

Woonghee Lee et al.

BIOINFORMATICS (2015)

Article Biochemistry & Molecular Biology

Apocalmodulin Itself Promotes Ion Channel Opening and Ca2+ Regulation

Paul J. Adams et al.

Article Multidisciplinary Sciences

Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels

Manu Ben Johny et al.

NATURE COMMUNICATIONS (2013)

Article Multidisciplinary Sciences

Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels

Noah G. Shuart et al.

NATURE COMMUNICATIONS (2011)

Article Biochemical Research Methods

MolProbity: all-atom structure validation for macromolecular crystallography

Vincent B. Chen et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Article Biochemical Research Methods

The HADDOCK web server for data-driven biomolecular docking

Sjoerd J. De Vries et al.

NATURE PROTOCOLS (2010)

Article Biochemical Research Methods

NMR: prediction of molecular alignment from structure using the PALES software

Markus Zweckstetter

NATURE PROTOCOLS (2008)

Article Biochemistry & Molecular Biology

HADDOCK versus HADDOCK: New features and performance of HADDOCK2.0 on the CAPRI targets

Sjoerd J. De Vries et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)

Article Biochemistry & Molecular Biology

Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron-specific regulator of calcium channels

JN Wingard et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Neurosciences

Regulation of cyclic nucleotide-gated channels

J Bradley et al.

CURRENT OPINION IN NEUROBIOLOGY (2005)

Review Biochemistry & Molecular Biology

Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels

MC Trudeau et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Multidisciplinary Sciences

Mechanism of calcium/calmodulin inhibition of rod cyclic nucleotide-gated channels

MC Trudeau et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Review Biochemistry & Molecular Biology

Calmodulin in action: Diversity in target recognition and activation mechanisms

KP Hoeflich et al.

Letter Multidisciplinary Sciences

Nomenclature for ion channel subunits

J Bradley et al.

SCIENCE (2001)

Review Physiology

Adaptation in vertebrate photoreceptors

GL Fain et al.

PHYSIOLOGICAL REVIEWS (2001)

Review Biochemistry & Molecular Biology

Modeling of loops in protein structures

A Fiser et al.

PROTEIN SCIENCE (2000)