期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 -, 期 -, 页码 -出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20220900
关键词
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资金
- French Agence Nationale de la Recherche [ANR-18-CE13-0007-01]
This article reviews studies on cell shape changes using biomimetic systems. By reconstructing actin networks inside cell-sized GUVs, the shape and mechanics of GUVs and some cell shape changes can be simulated and analyzed.
Cell shape changes that are fuelled by the dynamics of the actomyosin cytoskeleton control cellular processes such as motility and division. However, the mechanisms of interplay between cell membranes and actomyosin are complicated to decipher in the complex environment of the cytoplasm. Using biomimetic systems offers an alternative approach to studying cell shape changes in assays with controlled biochemical composition. Biomimetic systems allow quantitative experiments that can help to build physical models describing the processes of cell shape changes. This article reviews works in which actin networks are reconstructed inside or outside cell-sized Giant Unilamellar Vesicles (GUVs), which are models of cell membranes. We show how various actin networks affect the shape and mechanics of GUVs and how some cell shape changes can be reproduced in vitro using these minimal systems.
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