期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 -, 期 -, 页码 -出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20220271
关键词
-
资金
- Australian Research Council
- National Health and Medical Research Council of Australia
- [DE180100524]
- [APP1176209]
- [APP1138723]
- [APP1159106]
This article summarizes the important role of ERK1/2 in cell signaling, particularly in immune responses in immune cells. Additionally, it discusses the dysfunctional signaling of ERK1/2 in inflammatory diseases and explores the potential therapeutic benefits of targeting this pathway in inflammation.
Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a diverse array of signalling pathways for shaping cell behaviour and fate. More recently, studies have shown that ERK1/2 plays an essential role downstream of immune receptors to elicit inflammatory gene expression in response to infection and cell or tissue damage. Much of this work has studied ERK1/2 activation in Toll-like receptor (TLR) pathways, providing mechanistic insights into its recruitment, compartmentalisation and activation in cells of the innate immune system. In this review, we summarise the typical activation of ERK1/2 in growth factor receptor pathways before discussing its known roles in immune cell signalling with a focus downstream of TLRs. We examine emerging research uncover-ing evidence of dysfunctional ERK1/2 signalling in inflammatory diseases and discuss the potential therapeutic benefit of targeting ERK1/2 pathways in inflammation.
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