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Metabolite G-protein coupled receptor signaling: Potential regulation of eicosanoids

期刊

BIOCHEMICAL PHARMACOLOGY
卷 204, 期 -, 页码 -

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2022.115208

关键词

Metabolite; GPCR; Eicosanoid; Inflammation; Metabolic stress; Immunometabolism

资金

  1. Swedish Research Council [2018-02818, NNF15CC0018346, 0064142]
  2. Karolinska Institutet
  3. Konsul Th C Berghs Foundation [2356]
  4. Swedish Research Council [2018-02818] Funding Source: Swedish Research Council

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Eicosanoids, derived from arachidonic acid, are bioactive compounds that play crucial roles in physiology and disease, particularly in inflammatory conditions of multiple organ systems. Recent research has shown that G-protein coupled receptors can sense extracellular metabolites and regulate inflammatory responses, including eicosanoid production.
Eicosanoids are a family of bioactive compounds derived from arachidonic acid (AA) that play pivotal roles in physiology and disease, including inflammatory conditions of multiple organ systems. The biosynthesis of eicosanoids requires a series of catalytic steps that are controlled by designated enzymes, which can be regulated by inflammatory and stress signals via transcriptional and translational mechanisms. In the past decades, evidence have emerged indicating that G-protein coupled receptors (GPCRs) can sense extracellular metabolites, and regulate inflammatory responses including eicosanoid production. This review focuses on the recent advances of metabolite GPCRs research, their role in regulation of eicosanoid biosynthesis, and the link to pathophysiological conditions.

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