Study of biocompatibility, cytotoxic activity in vitro of a tetrazole-containing derivative of 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine

Article Chemistry, Physical

A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity

Olga Mikolaichuk et al.

Summary: This study presents a comprehensive investigation of a water-soluble substance from the class of triazine derivatives alkylating agents, including physicochemical properties, biological activity, and computational modeling.

JOURNAL OF MOLECULAR LIQUIDS (2022)

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Article Chemistry, Multidisciplinary

A new tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative: synthesis, interaction with DNA, and antitumor activity

O. Mikolaichuk et al.

Summary: The interaction between the synthesized 1,3,5-triazine derivative and DNA was studied, showing efficient binding and formation of stable associates. Additionally, the tetrazole-containing derivative exhibited cytostatic effects on liver adenocarcinoma and glioblastoma cells.

RUSSIAN CHEMICAL BULLETIN (2022)

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Review Oncology

Updates on Receptors Targeted by Heterocyclic Scaffolds: New Horizon in Anticancer Drug Development

Rajeev Kharb

Summary: Cancer is a global health threat caused by uncontrolled growth, with chemotherapy being a widely used method for tumor inhibition and eradication.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)

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Review Chemistry, Medicinal

1,3,5-Triazine: A versatile pharmacophore with diverse biological activities

Saumya Singh et al.

Summary: 1,3,5-Triazine and its derivatives are at the forefront of chemotherapeutic molecules due to their diverse and potent biological activities, including antibacterial, fungicidal, antimalarial, anticancer, antiviral, antimicrobial, anti-inflammatory, antiamoebic, and antitubercular activities.

ARCHIV DER PHARMAZIE (2021)

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Article Chemistry, Physical

Biocompatibility and bioactivity study of a cytostatic drug belonging to the group of alkylating agents of the triazine derivative class

Olga Mikolaichuk et al.

Summary: The article discusses the biocompatibility and bioactivity of a cytostatic agent, including its antioxidant properties and potential formation of adducts with DNA.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Review Pharmacology & Pharmacy

Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development

Mudasir Nabi Peerzada et al.

Summary: Heterocyclic scaffolds are widely used in drug design to target therapeutic molecules related to a variety of diseases, including tumors. Optimized molecular hybridization of these scaffolds may lead to the discovery of more effective anticancer therapeutics and prevent resistance development by specific targets.

PHARMACOLOGY & THERAPEUTICS (2021)

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Review Chemistry, Multidisciplinary