Hepatocyte-specific deletion of Bis causes senescence in the liver without deteriorating hepatic function

Article Biochemistry & Molecular Biology

BAG3 induces α-SMA expression in human fibroblasts and its over-expression correlates with poorer survival in fibrotic cancer patients

Margot De Marco et al.

Summary: Hypoxia and angiogenesis in solid tumors are closely linked to the development of fibrotic tissues, affecting patient prognosis. BAG3 plays a critical role in tumor fibrosis and may be a promising therapeutic target in cancer treatment.

JOURNAL OF CELLULAR BIOCHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

The role of BAG3 in health and disease: A Magic BAG of Tricks

Heng Lin et al.

Summary: This research categorizes BAG3 studies into different clusters and highlights key findings in areas such as cancer, cardiomyopathy, neurodegeneration, and viral propagation. By analyzing protein mass spectrometry data and mutation information, it provides insights into the universal and cell-type-specific interactions of BAG3 and its functional implications.

JOURNAL OF CELLULAR BIOCHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

An unexpected role for BAG3 in regulating PARP1 ubiquitination in oxidative stress-related endothelial damage

Naijin Zhang et al.

Summary: Oxidative stress-associated endothelial damage is the initiation factor of cardiovascular disease, and protein posttranslational modifications play critical roles in this process. This study identifies key molecular interactions and protein modifications of Bcl-2-associated athanogene 3 (BAG3) in oxidative stress-associated endothelial damage. BAG3 promotes the ubiquitination and degradation of poly(ADP-ribose) polymerase 1 (PARP1) by enhancing the E3 ubiquitin ligase WWP2. Furthermore, BAG3 itself is regulated by the acetyltransferase CREB-binding protein (CBP) and the deacetylase Sirtuin 2 (SIRT2).

REDOX BIOLOGY (2022)

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Article Gastroenterology & Hepatology

Senescence Connects Autophagy Deficiency to Inflammation and Tumor Progression in the Liver

Nazmul Huda et al.

Summary: This study found that cellular senescence frequently occurs in injured livers. By using mice deficient in key autophagy genes Atg 7 or Atg5, researchers discovered that cellular senescence can occur early in the disease process, triggering inflammation, and that inflammation and senescence can mutually enhance each other, resulting in long-term effects on liver injury and tumor progression.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Biochemistry & Molecular Biology

An Adult Mouse Model of Dilated Cardiomyopathy Caused by Inducible Cardiac-Specific Bis Deletion

Hye Hyeon Yun et al.

Summary: The study developed tamoxifen-inducible cardiomyocyte-specific BIS-KO mice and found that disruption of the Bis gene led to impaired heart function and heart failure. These mice may serve as a useful model for developing therapeutic interventions for dilated cardiomyopathy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology