期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 18, 期 -, 页码 1332-1337出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.18.138
关键词
boron; catalysis; hydroboration; nitrile; transborylation
In this study, a borane-catalysed hydroboration of nitriles to give primary amines is reported, with good yields and chemoselectivity observed. DFT calculations and mechanistic studies support the proposal of a double B-N/B-H transborylation mechanism.
The reduction of nitriles to primary amines is a useful transformation in organic synthesis, however, it often relies upon stoichiometric reagents or transition-metal catalysis. Herein, a borane-catalysed hydroboration of nitriles to give primary amines is reported. Good yields (48-95%) and chemoselectivity (e.g., ester, nitro, sulfone) were observed. DFT calculations and mechanistic studies support the proposal of a double B-N/B-H transborylation mechanism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据