期刊
BEHAVIOURAL BRAIN RESEARCH
卷 433, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbr.2022.113982
关键词
Caffeine; Episodic-like memory; Hippocampus; Dopamine
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq 014/2013]
Studies have shown that caffeine can improve the consolidation of episodic-like memory in Wistar rats, leading to increased dopamine turnover rate in the hippocampus.
Episodic-like memory (ELM) consists in the capacity of nonhuman animals to remember 'where' and 'when' a specific episode occurred ('what'). Previous studies have showed that Wistar rats can form an ELM, but not after a 24 h retention delay. On the other hand, it has been demonstrated that caffeine can improve episodic memory consolidation in humans. Therefore, we verified whether acute post-sample caffeine administration could improve ELM consolidation in Wistar rats, as well if it could be related to neurochemical changes in the pre-frontal cortex and hippocampus - regions related to episodic-like memory processing. 46 Male Wistar Rats, approximately 3 months-old, were divided into four groups as follows: untreated (n = 11), saline (n = 11), caffeine 10 mg /kg i.p (n = 12); caffeine 15 mg/kgi.p (n = 12) and tested in WWWhen/ELM task. The animals treated with caffeine in different dosages (10 mg/kg and 15 mg/kg) discriminated temporally and spatially the objects, respectively. These groups also showed a dopamine renewal rate in the hippocampus, suggesting that there was an increase in the turnover compared with the groups with no caffeine administration. We can conclude that caffeine leads to an improvement in the consolidation of the temporal ('what-when') and spatial ('what-where') aspects of episodic-like memory.
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