Widely cited publications of Michael Barany in 1964 and 1967 as tipping points in understanding myosin molecular motors

In 1964 Michael B ' ar ' any and colleagues published a paper ((M. B ' ar ' any, E. Gaetjens, K. B ' ar ' any, Karp E. Arch Biochem Biophys 106(1964)280-93. http://10.1016/0003-9861(64)90,189-4)) that has been one of the most cited papers in Archives of Biochemistry and Biophysics. This was followed in 1967 by another most cited paper (M. B ' ar ' any. J Gen Physiol 50(1967)197-218. https://doi.org/10.1085/jgp.50.6.197). I have commemorated these achievements as tipping points in the understanding of myosin motors in muscle function. Tipping points are generally defined as a temporal point in which a series of progressive advances (in this case the understanding of the relations between myosin ATP hydrolysis and muscle function) inspire more expansive, wide-ranging, sig-nificant changes. I first concisely summarize the background against which the papers came to publication as well as the unimaginable personal challenges faced by Michael and Kate B ' ar ' any. A final section summarizes the impact of these publications as key steps in the progression of contemporary understanding of diverse control of myosin ATPase activity with focus on the thick filaments in cardiac homeostasis, disorders, and as targets for therapeutic applications in translational investigations.

Automated summary

This article discusses the significant contributions of Michael B'ar'any and his colleagues in understanding myosin motors, with two of their papers being highly cited. The impact of these papers on the current understanding of myosin ATPase activity regulation is summarized, particularly in the context of cardiac homeostasis and diseases.