Cytotoxic derivatives of dichloroacetic acid and some metal complexes

This study outlines a number of studies of dichloroacetic acid (DCA) and some of its derivatives. Although DCA has low cytotoxic potencies, various structural modifications are described which result in potent cytotoxins. In particular, hybrid molecules created from DCA and other bioactive molecules whose modes of action differ from DCA are particularly promising as candidate anticancer agents. Considerable emphasis in this review is placed on various series of compounds that incorporate both platinum and DCA into their structures. In addition, the importance of the formulation of some of the bioactive compounds described herein is revealed.

Automated summary

This study provides an overview of several studies on dichloroacetic acid (DCA) and its derivatives. While DCA itself has low cytotoxicity, modifications have been made to produce potent cytotoxins. Hybrid molecules created by combining DCA with other bioactive molecules that have different modes of action show promise as potential anticancer agents. The review also emphasizes the importance of formulating the described bioactive compounds.