Nonenzymetic glucose sensitive device based on morchella shaped nickel-copper layered double hydroxide

We present a kind of three-dimensional core-shell hierarchical structure based on nickel-copper layered double hydroxide (Ni-Cu LDH), in which the morchella shaped Ni-Cu LDH shells were synthesized on the nanowireshaped Cu(OH)2 backbones and grown on Cu foam (CuF) substrate (Ni-Cu LDH@Cu(OH)2 NWs/CuF). The asfabricated nanocomposites were characterized and used for nonenzymetic glucose determination. The sensing properties of Ni-Cu LDH@Cu(OH)2 NWs/CuF were optimized by changing the mole ratio of Ni and Cu, demonstrating the optimized electrode (Ni:Cu = 4:2) has remarkable response/recovery times (1.5/3.5 s towards 200 mu M glucose), fine reproducibility and anti-interference properties, as well as anti-bending performance. Furthermore, the as-prepared optimized electrode was used to develop sensitive device by assembling with counter and reference electrodes into polydimethylsiloxane (PDMS)-based micro-cavity. The sensitive device exhibits a high sensitivity of 7.08 mu A/mu M/cm2, a good linear range of 0.006-1.6 mu M, and a detection boundary of 1.3 mu M. In addition, the developed device demonstrates good stability and can achieve the determination of glucose in human serum. Therefore, the morchella shaped Ni-Cu LDH hierarchical structures has shown an outstanding performance and can be used for detecting glucose level in serum samples, so it represents a promising sensitive material for constructing enzymeless glucose sensor.

Automated summary

A three-dimensional core-shell hierarchical structure based on nickel-copper layered double hydroxide (Ni-Cu LDH) is developed and used for nonenzymatic glucose determination. The optimized electrode shows remarkable response/recovery times, fine reproducibility, and anti-interference properties. By assembling with counter and reference electrodes, a sensitive device with high sensitivity is constructed for detecting glucose level in serum samples.