期刊
APPLIED SURFACE SCIENCE
卷 610, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.apsusc.2022.155290
关键词
Janus nanofibrous membrane; Superwettability; Exudate management; Wound healing
In this study, skin-inspired multilayer Janus composite nanofibrous membranes were designed and prepared as wound dressings with superhydrophilicity and superhydrophobicity. The membranes were investigated for their wettability, morphology, in-vitro release, cytotoxicity, antimicrobial activity, and healing effect. Results from animal experiments and histological analysis demonstrated that the composite membranes were more effective in improving the healing of full-thickness defect wounds and promoting the growth of collagen fibers and collagen deposition. The composite membranes consisted of a drug-loading layer with a superhydrophilic surface for self-pumping and drugs backflow, a hydrophobic polyvinylidene fluoride layer for delaying exudates loss, and a superhydrophobic coating with self-cleaning properties for avoiding the adhesion of foreign microorganisms.
In this paper, skin-inspired multilayer Janus composite nanofibrous membranes with superhydrophilicity and superhydrophobicity as a wound dressing were designed and prepared to manage and utilize the exudates. Wettability, morphology, in-vitro release, cytotoxicity, antimicrobial activity and healing effect were investigated. Animal experiment and histological analysis confirmed the composite membranes were more effective in improving the healing of full-thickness defect wound, the growth of collagen fibers and collagen deposition. The four-layer composite membranes include the drug-loading layer containing Ciprofloxacin (CIP) and Astaxanthin (ATX) with superhydrophilic surface for self-pumping and drugs backflow, the hydrophobic polyvinylidene fluoride layer for delaying the exudates loss, and the superhydrophobic coating with self-cleaning properties for avoiding adhesion of foreign microorganisms. The exudates were absorbed into the composite membrane and locked in the nanofiber network to avoid dehydration of the wound, meanwhile, CIP and ATX were delivered to the wound bed to effectively inhibit bacterial growth and stimulate tissue regeneration. These results demonstrate that skin-inspired Janus composite nanofibrous membrane is a promising wound dressing for promoting full-thickness skin defect wound healing, displaying its great potential applications in skin tissue engineering.
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