期刊
JOURNAL OF HEADACHE AND PAIN
卷 17, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s10194-016-0692-z
关键词
Migraine; Precuneus; Functional connectivity; Regional homogeneity
资金
- National Natural Science Foundation of China [81571658, 81201082, 81271302]
- Research Innovation Project of Shanghai Municipal Science and Technology Commission [14JC1404300]
- Open Fund of the National Key Laboratory of Medical and Neurobiology of Fudan University [SKLMN2014001]
- SHSMU-ION Research Center for Brain Disorders
- Clinical Science and Technology Innovation Project of Shanghai ShenKang Hospital Development Center [SHDC12015310]
- Shanghai Municipal Science and Technology Commission [16411953100]
Background: The precuneus/posterior cingulate cortex, which has been associated with pain sensitivity, plays a pivotal role in the default mode network. However, information regarding migraine-related alterations in resting-state brain functional connectivity in the default mode network and in local regional spontaneous neuronal activity is not adequate. Methods: This study used functional magnetic resonance imaging to acquire resting-state scans in 22 migraineurs without aura and in 22 healthy matched controls. Independent component analysis, a data-driven method, was used to calculate the resting-state functional connectivity of the default mode network in the patient and healthy control groups. Regional homogeneity (ReHo) was used to analyse the local features of spontaneous resting-state brain activity in the migraineurs without aura. Results: Compared with the healthy controls, migraineurs without aura showed increased functional connectivity in the left precuneus/posterior cingulate cortex within the default mode network and significant increase in ReHo values in the bilateral precuneus/posterior cingulate cortex, left pons and trigeminal nerve entry zone. In addition, functional connectivity was decreased between the areas with abnormal ReHo (using the peaks in the precuneus/posterior cingulate cortex) and other brain areas. Conclusions: The abnormalities in the precuneus/posterior cingulate cortex suggest that migraineurs without aura may exhibit information transfer and multimodal integration dysfunction and that pain sensitivity and pian processing may also be affected.
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