期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 38, 期 7-9, 页码 599-618出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2022.0126
关键词
long COVID-19; SARS-CoV-2; cardiovascular disorders; cardiac mitochondria; inflammation
Although COVID-19 has been categorized as an endemic, the long-term effect of the disease in causing multiorgan disorders, including cardiovascular dysfunction, is gaining attention. The role of cardiac mitochondria in mediating cardiac dysfunction post-SARS-CoV-2 infection remains unclear. Further studies are crucial to unravel the association between SARS-CoV-2 infection, mitochondrial dysfunction, and cardiovascular disorders.
Significance: Although corona virus disease 2019 (COVID-19) has now gradually been categorized as an endemic, the long-term effect of COVID-19 in causing multiorgan disorders, including a perturbed cardiovascular system, is beginning to gain attention. Nonetheless, the underlying mechanism triggering post-COVID-19 cardiovascular dysfunction remains enigmatic. Are cardiac mitochondria the key to mediating cardiac dysfunction post-severe acute respiratory syndrome coronavirus 2 (post-SARS-CoV-2) infection?Recent Advances: Cardiovascular complications post-SARS-CoV-2 infection include myocarditis, myocardial injury, microvascular injury, pericarditis, acute coronary syndrome, and arrhythmias (fast or slow). Different types of myocardial damage or reduced heart function can occur after a lung infection or lung injury. Myocardial/coronary injury or decreased cardiac function is directly associated with increased mortality after hospital discharge in patients with COVID-19. The incidence of adverse cardiovascular events increases even in recovered COVID-19 patients. Disrupted cardiac mitochondria postinfection have been postulated to lead to cardiovascular dysfunction in the COVID-19 patients. Further studies are crucial to unravel the association between SARS-CoV-2 infection, mitochondrial dysfunction, and ensuing cardiovascular disorders (CVD).Critical Issues: The relationship between COVID-19 and myocardial injury or cardiovascular dysfunction has not been elucidated. In particular, the role of the cardiac mitochondria in this association remains to be determined.Future Directions: Elucidating the cause of cardiac mitochondrial dysfunction post-SARS-CoV-2 infection may allow a deeper understanding of long COVID-19 and resulting CVD, thus providing a potential therapeutic target.
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